Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
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This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.Abstract:
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations
in bacteria, but that virus-resisting mutations are spontaneous. Their "fluctuation test" theory demonstrated that
bacteria were ideal subjects for genetic research.read more
Citations
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Comparison of rates of phenotypic variability in surface antigen expression in normal and cancerous human breast epithelial cells.
TL;DR: A method is described for measuring the rate of phenotypic variability in normal and neoplastic breast epithelial cells and found that the quantitative distribution among single cells was not random, for the cells tended to cluster around values that fit a geometric series.
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BACTERIAL DISSOCIATION A Critical Review of a Phenomenon of Bacterial Variation
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Short-term adaptation of microalgae in highly stressful environments: an experimental model analysing the resistance of Scenedesmus intermedius (Chlorophyceae) to the heavy metals mixture from the AznalcÓllar mine spill
Raquel Baos,Libertad García-Villada,Mar Agrelo,Victoria López-Rodas,Fernando Hiraldo,Eduardo Costas +5 more
TL;DR: The experimental model suggests that mutation is essential for adaptation of microalgal populations to environmental changes and rare spontaneous pre-adaptive mutation is enough to ensure the survival of microAlgal populations in contaminated environments when the population size is large enough.
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Design of a statistical method for the analysis of mutagenesis at the hypoxanthine-guanine phosphoribosyl transferase locus of cultured Chinese hamster ovary cells
Ronald D. Snee,Joseph David Irr +1 more
TL;DR: Mutagenesis data collected in the mammalian cell CHO/HGPRT assay were analyzed to study the distribution of the experimental errors associated with the test and transformed the data by using the power formula Y = (X + A) gamma where X is the observed mutation frequency, Y is the transformed frequency, and A and gamma are constants determined by the procedure of Box and Cox.
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Long CTG Tracts from the Myotonic Dystrophy Gene Induce Deletions and Rearrangements during Recombination at the APRT Locus in CHO Cells
James L. Meservy,R. Geoffrey Sargent,Ravi R. Iyer,Fung Chan,Gregory J. McKenzie,Robert D. Wells,John H. Wilson +6 more
TL;DR: These studies indicate that homologous recombination strongly destabilizes long tracts of CTG repeats, which are thought to arise from their capacity to form hairpin DNA structures.
References
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Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections
TL;DR: A bacteria-resistant-virus-resistant line is being developed from a cross between bacteria-susceptible-v virus-resistant and bacteria- resistant- virus-sUSceptible lines, which proved uniformly susceptible to a strain of mouse passage rabies virus.
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A Description of Some Color Variants Produced by Serratia marcescens, Strain 274
TL;DR: The work reported in this paper is of a preliminary nature and is concerned with the selection of a strain suitable for intensive study, the development of a special medium, and the recognition and characterization of specific variant types.