Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
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This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.Abstract:
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations
in bacteria, but that virus-resisting mutations are spontaneous. Their "fluctuation test" theory demonstrated that
bacteria were ideal subjects for genetic research.read more
Citations
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Development of efficient suicide mechanisms for biological containment of bacteria.
S M Knudsen,O H Karlström +1 more
TL;DR: Reduction of the mutational inactivation rate of the suicide system by duplication of thesuicide function augmented the efficiency of the suicidal system dramatically, allowing the construction of extremely efficient biological containment systems.
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Analysis of a method for selecting temperature-sensitive mutants of BHK cells.
TL;DR: The results suggest that such procedure is effective in enriching for non-leaky ts mutants and favors the isolation of mutants which at 39.5° are inhibited in the processes necessary for DNA synthesis and lose viability rapidly.
Journal ArticleDOI
Virus mutation frequencies can be greatly underestimated by monoclonal antibody neutralization of virions.
TL;DR: It is shown that incorporation of antibody into the plaque overlay medium (after virus penetration at 37 degrees C) can provide accurate estimates of genome frequencies of neutral monoclonal antibody-resistant mutant viruses in wt clones.
Journal ArticleDOI
rSalvador: An R Package for the Fluctuation Experiment.
TL;DR: In this paper, an R package named rSalvador is introduced to bring improvements to the field of fluctuation assay data analysis, which can alleviate three kinds of problems found in recent investigations: (i) resorting to partial plating without properly accounting for the effects of partial-plating; (ii) conducting attendant fitness assays without incorporating mutants' relative fitness in subsequent data analysis; and (iii) comparing mutation rates using methods that are in general inapplicable to fluctuation data.
Journal ArticleDOI
Integrating Antimicrobial Therapy with Host Immunity to Fight Drug-Resistant Infections: Classical vs. Adaptive Treatment.
TL;DR: This work compares aggressive and moderate antibiotic treatment, accounting for host immunity effects, and explains key parameters and dimensions, where an adaptive regime differs from classical treatment, bringing new insight into the ongoing debate of resistance management.
References
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Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections
TL;DR: A bacteria-resistant-virus-resistant line is being developed from a cross between bacteria-susceptible-v virus-resistant and bacteria- resistant- virus-sUSceptible lines, which proved uniformly susceptible to a strain of mouse passage rabies virus.
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A Description of Some Color Variants Produced by Serratia marcescens, Strain 274
TL;DR: The work reported in this paper is of a preliminary nature and is concerned with the selection of a strain suitable for intensive study, the development of a special medium, and the recognition and characterization of specific variant types.