Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
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This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.Abstract:
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations
in bacteria, but that virus-resisting mutations are spontaneous. Their "fluctuation test" theory demonstrated that
bacteria were ideal subjects for genetic research.read more
Citations
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The contribution of statistical physics to evolutionary biology.
TL;DR: Non-equilibrium statistical mechanics, travelling waves and Monte-Carlo methods, among others, have been used to study polygenic evolution, rates of adaptation and range expansions, indicating that evolutionary biology can further benefit from interactions with other areas of statistical physics.
Journal ArticleDOI
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells
TL;DR: A model system to analyze the effects of DNA methyltransferase 1 (Dnmt1) deficiency on DNA mismatch repair (MMR) in mouse embryonic stem (ES) cells found that DnMT1 deficiency led to a 7-fold increase in the microsatellite slippage rate.
Journal ArticleDOI
Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy.
Guido Stadler,Fedik Rahimov,Fedik Rahimov,Oliver D. King,Oliver D. King,Oliver D. King,Jennifer C. J. Chen,Jennifer C. J. Chen,Jennifer C. J. Chen,Jérôme D. Robin,Jérôme D. Robin,Kathryn R. Wagner,Kathryn R. Wagner,Kathryn R. Wagner,Jerry W. Shay,Charles P. Emerson,Charles P. Emerson,Charles P. Emerson,Woodring E. Wright +18 more
TL;DR: It is reported that telomere length may contribute to the pathogenesis of facioscapulohumeral muscular dystrophy (FSHD), the first known human disease in which TPE contributes to age-related phenotype.
Journal ArticleDOI
The mutagenic action of aliphatic epoxides.
TL;DR: The mutagenic action of 45 epoxides was investigates in Luria and Delbrück's fluctuation test with Klebsiella pneumoniae as test organism and the ring compound 4-vinylcyclohexenedioxide, used in electron microscopy that the antibiotic fosfomycin is among the more potent Mutagenic substances investigated in this study.
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Micromonas pusilla Virus: the Virus Growth Cycle and Associated Physiological Events Within the Host Cells; Host Range Mutation
TL;DR: Host range mutants of MPV exhibited variable infectivity in different strains of M. pusilla cells, suggesting that cells can mutate to virus resistance at the cell surface.
References
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Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections
TL;DR: A bacteria-resistant-virus-resistant line is being developed from a cross between bacteria-susceptible-v virus-resistant and bacteria- resistant- virus-sUSceptible lines, which proved uniformly susceptible to a strain of mouse passage rabies virus.
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A Description of Some Color Variants Produced by Serratia marcescens, Strain 274
TL;DR: The work reported in this paper is of a preliminary nature and is concerned with the selection of a strain suitable for intensive study, the development of a special medium, and the recognition and characterization of specific variant types.