Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
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TLDR
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.Abstract:
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations
in bacteria, but that virus-resisting mutations are spontaneous. Their "fluctuation test" theory demonstrated that
bacteria were ideal subjects for genetic research.read more
Citations
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Book ChapterDOI
Methods for Determining Spontaneous Mutation Rates
TL;DR: This chapter describes the proper design of a fluctuation assay, several of the methods used to calculate mutation rates, and ways to evaluate the results statistically.
Journal ArticleDOI
Phage therapy: the Escherichia coli experience.
TL;DR: This review discusses the potential of phage therapy with a specific example, namely Escherichia coli, and its applications in food production facilities and hospitals.
Journal ArticleDOI
Genetic analysis of the mitotic transmission of minichromosomes
TL;DR: The fidelity of the mitotic transmission of minichromosomes in S. cerevisiae is monitored by a novel visual assay that allows one to detect changes in plasmid copy number in individual mitotic divisions and the phenotypes of the mutations in ARS 1 and CEN3 are consistent with their function in replication and segregation, respectively.
Journal ArticleDOI
Mathematics is biology's next microscope, only better; biology is mathematics' next physics, only better.
TL;DR: Joel Cohen offers a historical and prospective analysis of the relationship between mathematics and biology in the 20th Century.
Journal ArticleDOI
Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene.
TL;DR: Levels of the RAD27 gene transcript are cell cycle regulated in a manner similar to those for several other genes whose products are known to be involved in DNA replication, and the possible role of Rad27 protein in DNA repair and replication is discussed.
References
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Journal ArticleDOI
Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections
TL;DR: A bacteria-resistant-virus-resistant line is being developed from a cross between bacteria-susceptible-v virus-resistant and bacteria- resistant- virus-sUSceptible lines, which proved uniformly susceptible to a strain of mouse passage rabies virus.
Journal ArticleDOI
A Description of Some Color Variants Produced by Serratia marcescens, Strain 274
TL;DR: The work reported in this paper is of a preliminary nature and is concerned with the selection of a strain suitable for intensive study, the development of a special medium, and the recognition and characterization of specific variant types.