Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
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This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.Abstract:
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations
in bacteria, but that virus-resisting mutations are spontaneous. Their "fluctuation test" theory demonstrated that
bacteria were ideal subjects for genetic research.read more
Citations
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What is adaptation by natural selection? Perspectives of an experimental microbiologist.
TL;DR: The development of the burgeoning field of experimental microbial evolution is traced, an experiment with Escherichia coli is described that has been running for almost 30 years, and other experiments in which natural selection has led to interesting dynamics and adaptive changes in microbial populations are highlighted.
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Inactivation of deoxyadenosine methyltransferase (dam) attenuates Haemophilus influenzae virulence
TL;DR: Dam activity appears to be necessary for both in vitro and in vivo virulence in a strain‐dependent fashion and may function as a regulator of gene expression including virulence factors.
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Spontaneous mutation rate is a plastic trait associated with population density across domains of life.
Rok Krašovec,Huw Richards,Danna R. Gifford,Charlie Hatcher,Katy J. Faulkner,Roman V. Belavkin,Alastair Channon,Elizabeth Aston,Andrew J. McBain,Christopher Knight +9 more
TL;DR: It is determined that there is indeed density-associated mutation-rate plasticity (DAMP) at multiple loci in both eukaryotes and bacteria, with up to 23-fold lower mutation rates at higher population densities, and that the degree of plasticity varies, even among closely related organisms.
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Factors determining frequency of plasmid cointegration mediated by insertion sequence IS1
TL;DR: In this paper, the authors demonstrate that mutants with deletions at either end of the insertion sequence of IS1 lose the ability to mediate cointegration of two plasmids.
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Effect of Chromosome Location on Bacterial Mutation Rates
TL;DR: Mutation rates at an intermediate locus were significantly higher than those at loci nearer to and farther from the replication origin, and the higher reversion rates were neither the result of an overall increase in mutation rates produced by the insertion at this location nor a function of the mutations' immediate neighbors, but rather a regional effect.
References
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Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections
TL;DR: A bacteria-resistant-virus-resistant line is being developed from a cross between bacteria-susceptible-v virus-resistant and bacteria- resistant- virus-sUSceptible lines, which proved uniformly susceptible to a strain of mouse passage rabies virus.
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A Description of Some Color Variants Produced by Serratia marcescens, Strain 274
TL;DR: The work reported in this paper is of a preliminary nature and is concerned with the selection of a strain suitable for intensive study, the development of a special medium, and the recognition and characterization of specific variant types.