Mutations of bacteria from virus sensitivity to virus resistance
Salvador E. Luria,Max Delbrück +1 more
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This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations in bacteria, but that virus-resisting mutations are spontaneous.Abstract:
This article reported Luria and Delbruck's breakthrough study in which they established that viruses do not induce mutations
in bacteria, but that virus-resisting mutations are spontaneous. Their "fluctuation test" theory demonstrated that
bacteria were ideal subjects for genetic research.read more
Citations
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Lysis and Lysis Inhibition with Escherichia coli Bacteriophage
TL;DR: Analysis of the pattern of mutability has made even the bacteria amenable to genetic investigation, and those bacterial viruses which have been most thoroughly investigated genetically belong to a group of seven phages and their mutant forms that comprise the T system.
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Adaptive Mutation by Deletions in Small Mononucleotide Repeats
TL;DR: A recombinational mechanism for adaptive mutation that functions through polymerase errors that persist as a result of a deficiency in post-synthesis mismatch repair is suggested.
Journal ArticleDOI
Origin of Bacterial Resistance to Antibiotics
TL;DR: Evidence is offered that bacterial resistance to penicillin and streptomycin is not induced by these compounds but originates spontaneously through genetic changes comparable to gene mutations.
Journal ArticleDOI
Cis-acting, recombination-stimulating activity in a fragment of the ribosomal DNA of S. cerevisiae
Ralph L. Keil,G. Shirleen Roeder +1 more
TL;DR: Evidence is found for a recombination-stimulating activity in the tandemly repeated ribosomal RNA genes of yeast that causes a localized stimulation of recombination when inserted at novel locations in the yeast genome.
References
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Inheritance of resistance of mice to enteric bacterial and neurotropic virus infections
TL;DR: A bacteria-resistant-virus-resistant line is being developed from a cross between bacteria-susceptible-v virus-resistant and bacteria- resistant- virus-sUSceptible lines, which proved uniformly susceptible to a strain of mouse passage rabies virus.
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A Description of Some Color Variants Produced by Serratia marcescens, Strain 274
TL;DR: The work reported in this paper is of a preliminary nature and is concerned with the selection of a strain suitable for intensive study, the development of a special medium, and the recognition and characterization of specific variant types.