Journal ArticleDOI
Nailfold videocapillaroscopy: a novel possible surrogate marker for the evaluation of peripheral microangiopathy in pulmonary arterial hypertension.
Alexandra Arvanitaki,George Giannakoulas,Eva Triantafyllidou,Haralampos Karvounis,Alexandros Garyfallos,George D. Kitas,Theodoros Dimitroulas,Theodoros Dimitroulas +7 more
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TLDR
Well-designed prospective trials are warranted to validate NVC as a biomarker, with clinical implications in the diagnostic evaluation, risk stratification, and overall management of PAH in the daily clinical setting.Abstract:
Nailfold videocapillaroscopy (NVC) changes in systemic sclerosis (SSc) are correlated with vascular complications, such as pulmonary arterial hypertension (PAH), supporting a potential link between peripheral and internal organ vasculopathy. The current stage of knowledge regarding NVC and PAH is discussed, focusing on the assessment of peripheral microangiopathy and a potential relationship with functional, echocardiographic, and haemodynamic markers of cardiac dysfunction. A comprehensive literature search was carried out to identify all studies focusing on NVC findings in patients with PAH, diagnosed with right heart catheterization. The majority of the studies examined NVC findings in patients with SSc-PAH, while three studies reported NVC abnormalities in patients with idiopathic PAH. Besides the pulmonary vasculature, a systemic component of microangiopathy seems to be involved in PAH. Well-designed prospective trials are warranted to validate NVC as a biomarker, with clinical implications in the diagnostic evaluation, risk stratification, and overall management of PAH in the daily clinical setting.read more
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Journal ArticleDOI
Peripheral microangiopathy in precapillary pulmonary hypertension: a nailfold video capillaroscopy prospective study.
Alexandra Arvanitaki,George Giannakoulas,Eva Triantafyllidou,Christos Feloukidis,Afroditi K. Boutou,Alexandros Garyfallos,Haralambos Karvounis,Theodoros Dimitroulas +7 more
TL;DR: In this paper, the presence of nailfold video-capillaroscopic (NVC) structural changes in patients with precapillary pulmonary hypertension and to identify possible associations of NVC measurements with markers of disease severity was investigated.
Journal ArticleDOI
Nailfold Capillaroscopy in Systemic Sclerosis Patients with and without Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.
Ioanna Minopoulou,Marieta Theodorakopoulou,Afroditi K. Boutou,Alexandra Arvanitaki,Alexandra Arvanitaki,Georgia Pitsiou,Michael Doumas,Pantelis Sarafidis,Theodoros Dimitroulas +8 more
TL;DR: In this article, the extent of peripheral microvasculopathy assessed through nailfold capillaroscopy might correlate with the presence of pulmonary arterial hypertension (PAH) in SSc patients.
Journal ArticleDOI
Peripheral microangiopathy in Eisenmenger syndrome: A nailfold video capillaroscopy study
Alexandra Arvanitaki,George Giannakoulas,Eva Triantafyllidou,Christos Feloukidis,Afroditi K. Boutou,Alexandros Garyfallos,Haralambos Karvounis,Gerhard-Paul Diller,Michael A. Gatzoulis,Theodoros Dimitroulas +9 more
TL;DR: In this paper, the authors demonstrate the presence of systemic microvascular abnormalities in patients with Eisenmenger syndrome using nailfold video-capillaroscopy (NVC) and identify potential correlations of nailfold capillaroscopic characteristics with non-invasive markers of systemic organ function.
Journal ArticleDOI
Non-Invasive Assessment of Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Athanasia Dara,Alexandra Arvanitaki,Alexandra Arvanitaki,Marieta Theodorakopoulou,Christos Athanasiou,Eleni Pagkopoulou,Afroditi K. Boutou +6 more
TL;DR: This review summarises and critically approach the current evidence of more systemic derangement of vascular function in PAH defined by novel, non-invasive methods employed for functional and morphological assessment of endothelium and microcirculation.
Journal ArticleDOI
Nailfold videocapillaroscopic changes in patients with pulmonary arterial hypertension associated with connective tissue diseases
Alexandra Arvanitaki,George Giannakoulas,Eva Triantafyllidou,Eleni Pagkopoulou,Afroditi K. Boutou,Alexandros Garyfallos,Haralambos Karvounis,Theodoros Dimitroulas +7 more
TL;DR: In this article, the authors investigated the presence of peripheral microangiopathy in patients with pulmonary arterial hypertension associated with CTDs (CTD-PAH) by exploring nailfold videocapillaroscopic (NVC) changes and identify possible associations of NVC characteristics with markers of disease severity.
References
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Journal ArticleDOI
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Journal ArticleDOI
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertension.
TL;DR: It is shown how genetic and metabolic abnormalities are inextricably linked to dysregulated immunity and adverse remodeling in the pulmonary arteries.