Nailfold Capillaroscopy in Systemic Sclerosis Patients with and without Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.
Ioanna Minopoulou,Marieta Theodorakopoulou,Afroditi K. Boutou,Alexandra Arvanitaki,Alexandra Arvanitaki,Georgia Pitsiou,Michael Doumas,Pantelis Sarafidis,Theodoros Dimitroulas +8 more
TLDR
In this article, the extent of peripheral microvasculopathy assessed through nailfold capillaroscopy might correlate with the presence of pulmonary arterial hypertension (PAH) in SSc patients.Abstract:
Systemic sclerosis (SSc)-related pulmonary arterial hypertension (SSc-PAH) is a leading cause of mortality in SSc. The extent of peripheral microvasculopathy assessed through nailfold capillaroscopy might correlate with the presence of PAH in SSc patients. We searched the PubMed, Cochrane Library, Scopus, and Web of Science databases and performed a random effects meta-analysis of observational studies comparing nailfold capillaroscopic alterations in SSc-PAH versus SSc-noPAH patients. Weighted mean differences (WMD) with the corresponding confidence intervals (CIs) were estimated. The quality of the included studies was evaluated using a modified Newcastle–Ottawa scale. Seven studies with 101 SSc-PAH and 277 SSc-noPAH participants were included. Capillary density was marginally reduced in the SSc-PAH group (WMD: −1.0, 95% CI: −2.0 to 0.0, I2 = 86%). This effect was strengthened once PAH diagnosis was confirmed by right heart catheterization (WMD: −1.2, 95% CI: −2.3 to −0.1, I2 = 85%). An increase in capillary loop width was observed in SSc-PAH compared to SSc-noPAH patients (WMD: 10.9, 95% CI: 2.5 to 19.4, I2 = 78%). Furthermore, SSc-PAH patients had a 7.3 times higher likelihood of active or late scleroderma pattern (95% CI: 3.0 to 18.0, I2 = 4%). SSc-PAH patients presented with worse nailfold capillaroscopic findings compared to SSc-noPAH patients.read more
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Nailfold Videocapillaroscopy for the Evaluation of Peripheral Microangiopathy in Rheumatoid Arthritis
TL;DR: In this article , the authors provide an overview of NVC as a valuable clinical aid for the assessment of peripheral microcirculation in RA, along with associations with disease-related characteristics.
Journal ArticleDOI
Nailfold videocapillaroscopic changes in patients with pulmonary arterial hypertension associated with connective tissue diseases
Alexandra Arvanitaki,George Giannakoulas,Eva Triantafyllidou,Eleni Pagkopoulou,Afroditi K. Boutou,Alexandros Garyfallos,Haralambos Karvounis,Theodoros Dimitroulas +7 more
TL;DR: In this article, the authors investigated the presence of peripheral microangiopathy in patients with pulmonary arterial hypertension associated with CTDs (CTD-PAH) by exploring nailfold videocapillaroscopic (NVC) changes and identify possible associations of NVC characteristics with markers of disease severity.
Journal ArticleDOI
Pulmonary Hypertension: Current Diagnosis, Approach and Treatment at the Dawn of the New European Guidelines
TL;DR: The most recent publication of the new European Guidelines for the diagnosis and treatment of pulmonary hypertension, a collaboration between the European Society of Cardiology and the European Respiratory Society, indicates a turning point in the field of pulmonary pulmonary hypertension.
Journal ArticleDOI
Peripheral Microangiopathy Changes in Pulmonary Arterial Hypertension Related to Systemic Sclerosis: Data From a Multicenter Observational Study
Dilia Giuggioli,Valeria Riccieri,Edoardo Cipolletta,N. Del Papa,Francesca Ingegnoli,Amelia Spinella,Greta Pellegrino,Anna Maria Risa,Marco de Pinto,Silvia Papa,Giuseppe Armentaro,R. De Angelis +11 more
TL;DR: It is confirmed that a higher degree of peripheral nailfold microangiopathy is more common in SSc-PAH patients, and the concept that NVC changes may run parallel with similar abnormalities inside pulmonary microcirculation is strengthened.
Journal ArticleDOI
Nailfold Videocapillaroscopy for Non-Invasive Assessment of Microcirculation and Prognostic Correlation with Endothelial Dysfunction, Cardiovascular Risk Factors, and Non-HLA Antibodies in Heart Transplant Recipients: A Pilot Study
Dorota Sikorska,Dorota Kaminska,Rusan Catar,Dashan Wu,Hongfan Zhao,Pin Wang,Julian Kamhieh-Milz,Mirosław Banasik,Mariusz Kusztal,Magdalena Cielecka,M. Zakliczynski,Rafał Rutkowski,Katarzyna Korybalska,Harald Heidecke,Guido Moll,Włodzimierz Samborski +15 more
TL;DR: In this paper , a non-invasive imaging evaluation of the heart transplant patients with underlying cardiovascular disease (CVD) using nailfold video-capillaroscopy (NVC) was conducted.
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TL;DR: The ACR/EULAR classification criteria for SSc performed better than the 1980 ACR criteria and should allow for more patients to be classified correctly as having the disease.
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