Journal ArticleDOI
Nanoemulsion strategy for olmesartan medoxomil improves oral absorption and extended antihypertensive activity in hypertensive rats.
Bapi Gorain,Hira Choudhury,Amit Kundu,Lipi Sarkar,Sanmoy Karmakar,Parasuraman Jaisankar,Tapan Kumar Pal +6 more
TLDR
Investigating the findings of the present investigations indicated that the nanoemulsion of OM (OMF6) could significantly enhance the oral bioavailability of relatively insoluble OM contributing to improved clinical application.About:
This article is published in Colloids and Surfaces B: Biointerfaces.The article was published on 2014-03-01. It has received 115 citations till now. The article focuses on the topics: Olmesartan & Bioavailability.read more
Citations
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Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: Formulation development, stability issues, basic considerations and applications.
TL;DR: This article reviews the progressive advancement in the delivery of medicament via nanoemulsion with special reference to the dermal and transdermal administration and attempted to explore the most suitable semi solid dosage form for the particular type of nanoemulsions.
Journal ArticleDOI
Oral Bioavailability: Issues and Solutions via Nanoformulations
Kamla Pathak,Smita Raghuvanshi +1 more
TL;DR: The potential of nanomedicines to improve the pharmacokinetics of drugs via nanoformulations is confirmed, and nanotechnological approaches to particle design and formulation are beginning to expand the market for many drugs with improved bioavailability and therapeutics.
Journal ArticleDOI
Recent Update on Nanoemulgel as Topical Drug Delivery System.
Hira Choudhury,Bapi Gorain,Manisha Pandey,Lipika Alok Chatterjee,Pinaki Sengupta,Arindam Das,Nagashekhara Molugulu,Prashant Kesharwani +7 more
TL;DR: It could be inferred that nanoemulgel can be a better and effective drug delivery tool for the topical system.
Journal ArticleDOI
Nanotechnology based approaches for anti-diabetic drugs delivery.
Prashant Kesharwani,Bapi Gorain,Siew Yeng Low,Siew-Ann Tan,Emily Chai Siaw Ling,Yin Khai Lim,Chuan Ming Chin,Pei Yee Lee,Chun Mey Lee,Chun Haw Ooi,Hira Choudhury,Manisha Pandey +11 more
TL;DR: An overview on distinctive features of each nano-based drug delivery system for diabetic treatment and current NPs applications in diabetes management is provided.
Journal ArticleDOI
Nanotechnology Based Approaches for Enhancing Oral Bioavailability of Poorly Water Soluble Antihypertensive Drugs.
TL;DR: Various nanocarriers available in oral drug administration are focused on for improving solubility profile, dissolution, and consequently bioavailability of hydrophobic antihypertensive drugs.
References
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
TL;DR: NO released from endothelial cells is indistinguishable from EDRF in terms of biological activity, stability, and susceptibility to an inhibitor and to a potentiator.
Journal ArticleDOI
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
TL;DR: It is concluded that Caco-2 cells grown on collagen-coated polycarbonate membranes should represent a valuable transport model system for the small intestinal epithelium.
Journal Article
Angiotensin II receptors and angiotensin II receptor antagonists.
Pieter B.M.W.M. Timmermans,P. C. Wong,Andrew T. Chiu,William F. Herblin,P. Benfield,David J. Carini,R. J. Lee,Ruth R. Wexler,J. A. M. Saye,Ronald D. Smith +9 more
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Self-emulsifying drug delivery systems (SEDDS) for improved oral delivery of lipophilic drugs.
R. Neslihan Gürsoy,Simon Benita +1 more
TL;DR: Self-emulsifying drug delivery systems (SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, can be used for the design of formulations in order to improve the oral absorption of highly lipophilic drug compounds as discussed by the authors.
Journal ArticleDOI
Design and Production of Nanoparticles Formulated From Nano-Emulsion Templates-A Review
TL;DR: A link between nano-emulsion formulation methods and nanoparticle generation is proposed, while at the same time bearing in mind the above-mentioned parameters for active molecule encapsulation.