Journal ArticleDOI
Nanosuspensions of alendronate with gallium or gadolinium attenuate neointimal hyperplasia in rats
Hila Epstein,Vardit Berger,Idit Levi,Galit Eisenberg,Nickolay Koroukhov,Jianchuan Gao,Gershon Golomb +6 more
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TLDR
It is hypothesized that a self-suspendable nanoparticulate dosage form, with a minimum amount of expients, could be formulated by complexing the negatively charged alendronate with gallium or gadolinium, and that a synergistic biological effect could be obtained by nanosuspensions of alendronsate with these counter ions.About:
This article is published in Journal of Controlled Release.The article was published on 2007-02-26. It has received 39 citations till now. The article focuses on the topics: Neointimal hyperplasia.read more
Citations
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Journal ArticleDOI
Physical and chemical stability of drug nanoparticles
TL;DR: The physical and chemical stability of drug nanoparticles, including their mechanisms and corresponding characterization techniques are reviewed, and a few common strategies to overcome stability issues are discussed.
Book ChapterDOI
Methods for characterization of nanoparticles
Ajeet Kumar,Chandra K. Dixit +1 more
TL;DR: This chapter provides details of the challenges and associated problems which usually arise during the characterization of the nanomaterials and ways to resolve the issues with an emphasis on minimizing the associated interferences.
Journal ArticleDOI
Delivery of serotonin to the brain by monocytes following phagocytosis of liposomes.
Eyal Afergan,Hila Epstein,Rachel Dahan,Nickolay Koroukhov,Keren Rohekar,Haim D. Danenberg,Gershon Golomb +6 more
TL;DR: The same brain uptake of both empty and serotonin liposome, the co-localization in the brain of both markers, and the unchanged ratio of (3)H:(14)C suggest that intact liposomes entered the brain.
Journal ArticleDOI
Physicochemical parameters affecting liposomal bisphosphonates bioactivity for restenosis therapy: Internalization, cell inhibition, activation of cytokines and complement, and mechanism of cell death
Hila Epstein-Barash,Dikla Gutman,Ela Markovsky,Galit Mishan-Eisenberg,Nickolay Koroukhov,Janos Szebeni,Gershon Golomb +6 more
TL;DR: It was found that monocyte/macrophage inhibition and cytokine activation depend on the cell type, with a limited correlation to the bioactivity obtained in the rat and rabbit models of restenosis.
Journal ArticleDOI
Preparation of Alendronate Liposomes for Enhanced Stability and Bioactivity: In Vitro and In Vivo Characterization
Hila Epstein,Dikla Gutman,Einat Cohen-Sela,Elran Haber,Omar Elmalak,Nickolay Koroukhov,Haim D. Danenberg,Gershon Golomb +7 more
TL;DR: In vitro assessment may provide a valuable tool in assessing in vivo integrity of liposomal formulations, as determined by the insignificant changes in vesicle size, drug leakage, lipid and drug stability, in vitro bioactivity (macrophages inhibition), as well as in vivo in depleting circulating monocytes and inhibition of restenosis in rabbits.
References
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Journal ArticleDOI
Phosphorus Assay in Column Chromatography
TL;DR: If the highest accuracy was not required, the following manipulations simplified and speeded multiple total phosphorus determinations on the eluates from column chromatographic separations.
Journal ArticleDOI
Inflammation, Atherosclerosis, and Coronary Artery Disease
TL;DR: The evidence is recounted that atherosclerosis, the main cause of CAD, is an inflammatory disease in which immune mechanisms interact with metabolic risk factors to initiate, propagate, and activate lesions in the arterial tree.
Journal ArticleDOI
Recent advances with liposomes as pharmaceutical carriers.
TL;DR: For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Comparative Properties and Methods of Preparation of Lipid Vesicles (Liposomes)
TL;DR: This research attacked the mode of action of phosphatidylcholine-like deposits in response to the presence of ribonucleic acid by exploiting its role as a “spatially aggregating substance” in the response to EMT.
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Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications.
N. van Rooijen,A Sanders +1 more