Journal ArticleDOI
Natural alkaloid and polyphenol compounds targeting lipid metabolism: Treatment implications in metabolic diseases.
Can Cheng,Zhenzhen Li,Xu Zhao,Chaoliang Liao,Jing Quan,Ann M. Bode,Ya Cao,Xiangjian Luo,Xiangjian Luo +8 more
TLDR
Alkaloid and polyphenol are promising candidates for metabolic diseases to ameliorate lipid metabolism abnormalities to improve or even curing lipid metabolism-related diseases.About:
This article is published in European Journal of Pharmacology.The article was published on 2020-03-05. It has received 37 citations till now. The article focuses on the topics: Lipid metabolism.read more
Citations
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ACSL family: The regulatory mechanisms and therapeutic implications in cancer.
TL;DR: In this article, the differential regulatory mechanisms of the ACSL family members as well as their functions in carcinogenesis were addressed. And the clinical therapeutic implications of ACSLs, which might serve as valuable biomarkers and therapeutic targets for precision cancer treatment.
Betaine chemistry, roles, and potential use in liver disease
TL;DR: A significant amount of data from animal models of liver disease indicates that administration of betaine can halt and even reverse progression of the disruption of liver function, and the accumulated data indicate that carefully controlled additional investigations in humans are merited.
Journal Article
Lipid droplet and its implication in cancer progression.
TL;DR: In this paper, the authors summarize the composition, synthesis and decomposition of lipid droplets, and highlight their role in carcinogenesis and malignant development of cancers in eukaryotic cells.
Journal ArticleDOI
Material, antibacterial and anticancer properties of natural polyphenols incorporated soy protein isolate: A review
TL;DR: In this article, a review of the properties of soy protein isolate (SPI) films is presented, focusing on material characterization, antimicrobial, antioxidant properties and biodegradation behavior of several natural polyphenols incorporated in SPI films.
Journal ArticleDOI
Recent Advances on Marine Alkaloids from Sponges
TL;DR: This article summarized 149 marine alkaloids from sponges based on their structures and bioactivities reported from 2015 to 2020 and analyzed the production environment of marine spongees with rich alkaloid concentrations.
References
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Journal ArticleDOI
Lipid metabolism in cancer
Claudio R. Santos,Almut Schulze +1 more
TL;DR: This review will examine some of the alterations in lipid metabolism that have been reported in cancer, at both cellular and organismal levels, and discuss how they contribute to different aspects of tumourigenesis.
Journal ArticleDOI
Metabolic Dysregulation and Adipose Tissue Fibrosis: Role of Collagen VI†
Tayeba Khan,Eric S. Muise,Puneeth Iyengar,Puneeth Iyengar,Zhao V. Wang,Manisha Chandalia,Nicola Abate,Bei B. Zhang,Paolo Bonaldo,Streamson C. Chua,Philipp E. Scherer +10 more
TL;DR: It is suggested that weakening the extracellular scaffold of adipocytes enables their stress-free expansion during states of positive energy balance, which is consequently associated with an improved inflammatory profile and implicating “adipose tissue fibrosis” as a hallmark of metabolically challenged adipocytes.
Journal ArticleDOI
Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice
TL;DR: This article investigated the effect of curcumin, the major polyphenol in turmeric spice, on angiogenesis, adipogenesis, differentiation, apoptosis, and gene expression involved in lipid and energy metabolism in 3T3-L1 adipocyte in cell culture systems.
Journal ArticleDOI
Integrative physiology of human adipose tissue
TL;DR: Adipose tissue is now recognised as a highly active metabolic and endocrine organ, and its functions are regulated by multiple external influences such as autonomic nervous system activity, the rate of blood flow and the delivery of a complex mix of substrates and hormones in the plasma.
Journal ArticleDOI
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease
TL;DR: Fructose metabolism supports DNL more strongly than HFD and hepatic DNL is a central abnormality in NAFLD, and disrupting fructose metabolism in the liver may provide a new therapeutic option for the treatment of NAFLd.
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Hepatic AMP Kinase as a Potential Target for Treating Nonalcoholic Fatty Liver Disease: Evidence from Studies of Natural Products
Gang Xu,Kaixun Huang,Jun Zhou +2 more