Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution.
Qasim A. Majid,Annabelle T. R. Fricker,David A. Gregory,Natalia Davidenko,Olivia Hernandez Cruz,Richard J. Jabbour,Thomas J. Owen,Pooja Basnett,Barbara Lukasiewicz,Molly M. Stevens,Serena M. Best,Ruth E. Cameron,Sanjay Sinha,Sian E. Harding,Ipsita Roy +14 more
TLDR
Overall, these biomaterials have proven to be highly promising, displaying robust biocompatibility and, when combined with cells, an ability to enhance post-MI cardiac function in pre-clinical models.Abstract:
Cardiovascular diseases (CVD) constitute a major fraction of the current major global diseases and lead to about 30% of the deaths, i.e., 17.9 million deaths per year. CVD include coronary artery disease (CAD), myocardial infarction (MI), arrhythmias, heart failure, heart valve diseases, congenital heart disease, and cardiomyopathy. Cardiac Tissue Engineering (CTE) aims to address these conditions, the overall goal being the efficient regeneration of diseased cardiac tissue using an ideal combination of biomaterials and cells. Various cells have thus far been utilized in pre-clinical studies for CTE. These include adult stem cell populations (mesenchymal stem cells) and pluripotent stem cells (including autologous human induced pluripotent stem cells or allogenic human embryonic stem cells) with the latter undergoing differentiation to form functional cardiac cells. The ideal biomaterial for cardiac tissue engineering needs to have suitable material properties with the ability to support efficient attachment, growth, and differentiation of the cardiac cells, leading to the formation of functional cardiac tissue. In this review, we have focused on the use of biomaterials of natural origin for CTE. Natural biomaterials are generally known to be highly biocompatible and in addition are sustainable in nature. We have focused on those that have been widely explored in CTE and describe the original work and the current state of art. These include fibrinogen (in the context of Engineered Heart Tissue, EHT), collagen, alginate, silk, and Polyhydroxyalkanoates (PHAs). Amongst these, fibrinogen, collagen, alginate, and silk are isolated from natural sources whereas PHAs are produced via bacterial fermentation. Overall, these biomaterials have proven to be highly promising, displaying robust biocompatibility and, when combined with cells, an ability to enhance post-MI cardiac function in pre-clinical models. As such, CTE has great potential for future clinical solutions and hence can lead to a considerable reduction in mortality rates due to CVD.read more
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Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative
TL;DR: Fibroblasts of high population doubling level propagated in vitro, which have left the cell cycle, can carry out the contraction at least as efficiently as cycling cells as discussed by the authors, and the potential uses of the system as an immu- nologically tolerated "tissue" for wound hea ing and as a model for studying fibroblast function are discussed.
Nanowired three-dimensional cardiac patches
Tal Dvir,Tal Dvir,Brian P. Timko,Brian P. Timko,Mark D. Brigham,Shreesh R. Naik,Sandeep S. Karajanagi,Sandeep S. Karajanagi,Oren Levy,Oren Levy,Hongwei Jin,Kevin Kit Parker,Robert Langer,Daniel S. Kohane +13 more
TL;DR: Incorporating gold nanowires into scaffolds used to create heart patches can improve electrical communication between cells and enhance the growth of tissues as discussed by the authors, which can improve the electrical communication among cells.
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Opportunities and challenges in cardiac tissue engineering from an analysis of two decades of advances
TL;DR: This retrospective analysis led us to identify key milestones and to outline a set of opportunities, along with their associated challenges, for the further advancement of engineered human cardiac tissues.
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Recent Applications of Electrospun Nanofibrous Scaffold in Tissue Engineering
H A Owida,Jamal Al-Nabulsi,F. A. Alnaimat,Muhammad Al-Ayyad,Nidal M. Turab,A. Al Sharah,Murad Shakur +6 more
TL;DR: An overview of attempts to construct nanofibrous meshes as tissue-engineered scaffolds for various tissues such as bone, cartilage, cardiovascular, and skin tissues is given.
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TPU-based antiplatelet cardiovascular prosthesis prepared using fused deposition modelling
Juan Domínguez-Robles,Emilia Utomo,Victoria A. Cornelius,Qonita Kurnia Anjani,Anna Korelidou,Zoilo Gonzalez,Ryan F. Donnelly,Andriana Margariti,Marc Delgado-Aguilar,Quim Tarrés,Eneko Larraňeta +10 more
TL;DR: In this paper , an antiplatelet drug, dipyridamole (DIP), was combined with TPU using hot-melt extrusion to prepare tubular grafts.
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