Journal ArticleDOI
Necrotizing Soft-Tissue Infections
Dennis L. Stevens,Amy E. Bryant +1 more
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The hallmarks of necrotizing fasciitis are friable superficial fascia, gray exudate without pus, and widespread tissue destruction.Abstract:
The hallmarks of necrotizing fasciitis are friable superficial fascia, gray exudate without pus, and widespread tissue destruction. The infection is either polymicrobial or monomicrobial. Early surgical debridement and appropriate antibiotics are crucial for recovery.read more
Citations
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Severe group a streptococcal infections associated with a toxic shock-life syndrome and scarlet fever toxin
TL;DR: From the study of this cluster of severe streptococcal infections with a toxic shock-like syndrome, it is concluded that in the Rocky Mountain region, more virulent group A Streptococci have reappeared that produce the pyrogenic toxin A associated with scarlet fever.
Journal ArticleDOI
Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection
Felipe A. Pinho-Ribeiro,Buket Baddal,Rianne Haarsma,Maghnus O'Seaghdha,Nicole J. Yang,Kimbria J. Blake,Makayla Portley,Waldiceu A. Verri,James B. Dale,Michael R. Wessels,Michael R. Wessels,Isaac M. Chiu +11 more
TL;DR: It is concluded that targeting the peripheral nervous system and blocking neuro-immune communication is a promising strategy to treat highly invasive bacterial infections.
Journal ArticleDOI
Necrotizing Soft Tissue Infection: Diagnostic Accuracy of Physical Examination, Imaging, and LRINEC Score: A Systematic Review and Meta-Analysis.
Shannon M. Fernando,Alexandre Tran,Wei Cheng,Bram Rochwerg,Kwadwo Kyeremanteng,Kwadwo Kyeremanteng,Andrew J.E. Seely,Kenji Inaba,Jeffrey J. Perry,Jeffrey J. Perry +9 more
TL;DR: Accuracy of physical examination, imaging, and Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score in diagnosis of necrotizing soft tissue infection (NSTI) in adults with a hard tissue infection clinically concerning for NSTI is summarized.
Journal ArticleDOI
2018 WSES/SIS-E consensus conference: recommendations for the management of skin and soft-tissue infections
Massimo Sartelli,Xavier Guirao,Timothy Craig Hardcastle,Yoram Kluger,Marja A. Boermeester,Kemal Rasa,Luca Ansaloni,Federico Coccolini,Philippe Montravers,Fikri M. Abu-Zidan,Michele Bartoletti,Matteo Bassetti,Offir Ben-Ishay,Walter L. Biffl,Osvaldo Chiara,Massimo Chiarugi,Raul Coimbra,Francesco Giuseppe De Rosa,Belinda De Simone,Salomone Di Saverio,Maddalena Giannella,George Gkiokas,Vladimir Khokha,Francesco M. Labricciosa,Ari Leppäniemi,Andrey Litvin,Ernest E. Moore,Ionut Negoi,Leonardo Pagani,Maddalena Peghin,Edoardo Picetti,Tadeja Pintar,Guntars Pupelis,Ines Rubio-Perez,Boris Sakakushev,Helmut Segovia-Lohse,Gabriele Sganga,Vishal G Shelat,Michael Sugrue,Antonio Tarasconi,Cristian Tranà,Jan Ulrych,Pierluigi Viale,Fausto Catena +43 more
TL;DR: A task force of experts met in Bertinoro, Italy, on June 28, 2018, for a specialist multidisciplinary consensus conference under the auspices of the World Society of Emergency Surgery (WSES) and the Surgical Infection Society Europe (SIS-E).
Journal ArticleDOI
Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis
TL;DR: Early surgical debridement lowers the mortality rate for NSTI with almost 50%.
References
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Journal ArticleDOI
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
Andrew Rhodes,Laura Evans,Waleed Alhazzani,Mitchell M. Levy,Massimo Antonelli,Ricard Ferrer,Anand Kumar,Jonathan E. Sevransky,Charles L. Sprung,Mark E. Nunnally,Bram Rochwerg,Gordon D. Rubenfeld,Derek C. Angus,Djillali Annane,Richard Beale,Geoffrey J. Bellinghan,Gordon R. Bernard,Jean Daniel Chiche,Craig M. Coopersmith,Daniel De Backer,Craig French,Seitaro Fujishima,Herwig Gerlach,Jorge Hidalgo,Steven M. Hollenberg,Alan E. Jones,Dilip R. Karnad,Ruth M. Kleinpell,Younsuck Koh,Thiago Lisboa,Flávia Ribeiro Machado,John J. Marini,John C. Marshall,John E. Mazuski,Lauralyn McIntyre,Anthony S. McLean,Sangeeta Mehta,Rui Moreno,John Myburgh,Paolo Navalesi,Osamu Nishida,Tiffany M. Osborn,Anders Perner,Colleen M. Plunkett,Marco Ranieri,Christa A. Schorr,Maureen A. Seckel,Christopher W. Seymour,Lisa Shieh,Khalid A. Shukri,Steven Q. Simpson,Mervyn Singer,B. Taylor Thompson,Sean R. Townsend,Thomas Van der Poll,Jean Louis Vincent,W. Joost Wiersinga,Janice L. Zimmerman,R. Phillip Dellinger +58 more
TL;DR: Although a significant number of aspects of care have relatively weak support, evidence-based recommendations regarding the acute management of sepsis and septic shock are the foundation of improved outcomes for these critically ill patients with high mortality.
Journal ArticleDOI
Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America
Dennis L. Stevens,Alan L. Bisno,Henry F. Chambers,E. Patchen Dellinger,Ellie J. C. Goldstein,Sherwood L. Gorbach,Jan V. Hirschmann,Sheldon L. Kaplan,Jose G. Montoya,James C. Wade,R. M. Alden +10 more
TL;DR: This guideline addresses the wide array of SSTIs that occur in this population and emphasizes the importance of clinical skills in promptly diagnosing SSTI, identifying the pathogen, and administering effective treatments in a timely fashion.
Journal ArticleDOI
The LRINEC (Laboratory Risk Indicator for Necrotizing Fasciitis) score: a tool for distinguishing necrotizing fasciitis from other soft tissue infections.
TL;DR: The LRINEC score, based on laboratory tests routinely performed for the evaluation of severe soft tissue infections, is a robust score capable of detecting even clinically early cases of necrotizing fasciitis.
Journal ArticleDOI
Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A
Dennis L. Stevens,Martha H. Tanner,Jay Winship,Raymond Swarts,Kristen Ries,Patrick M. Schlievert,Edward H. Kaplan +6 more
TL;DR: Twenty patients from the Rocky Mountain region who had group A streptococcal infections from 1986 to 1988 that were remarkable for the severity of local tissue destruction and life-threatening systemic toxicity are described.
Journal ArticleDOI
Necrotizing Fasciitis Caused by Community-Associated Methicillin-Resistant Staphylococcus aureus in Los Angeles
Loren G. Miller,Francoise Perdreau-Remington,Gunter Rieg,Sheherbano Mehdi,Josh Perlroth,Arnold S. Bayer,Angela W. Tang,Tieu O. Phung,Brad Spellberg +8 more
TL;DR: In areas in which community-associated MRSA infection is endemic, empirical treatment of suspected necrotizing fasciitis should include antibiotics predictably active against this pathogen.