Journal ArticleDOI
Negative sputum smear results in HIV-positive patients with pulmonary tuberculosis in Lusaka, Zambia
Alison M. Elliott,Alison M. Elliott,K. Namaambo,B.W. Allen,N. Luo,Richard J. Hayes,J. O. M. Pobee,K. P. W. J. Mcadam +7 more
TLDR
The findings imply that cases of HIV-associated pulmonary tuberculosis may frequently be missed and emphasise the need for new diagnostic methods.About:
This article is published in Tubercle and Lung Disease.The article was published on 1993-06-01. It has received 199 citations till now. The article focuses on the topics: Sputum culture & Sputum.read more
Citations
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Journal ArticleDOI
Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli
Marcel A. Behr,S. A. Warren,Hugh Salamon,Philip C. Hopewell,A. Ponce de Leon,Charles L. Daley,Peter M. Small +6 more
TL;DR: In San Francisco, the acid-fast-bacilli smear identifies the most infectious patients, but patients with smear-negative culture-positive tuberculosis appear responsible for about 17% of tuberculosis transmission.
Journal ArticleDOI
Sputum processing methods to improve the sensitivity of smear microscopy for tuberculosis: a systematic review
Karen R Steingart,Vivienne Ng,Megan Henry,Philip C. Hopewell,Andrew Ramsay,Jane Cunningham,Richard Urbanczik,Mark D. Perkins,Mohamed Abdel Aziz,Madhukar Pai +9 more
TL;DR: A systematic review of physical and chemical sputum processing methods suggested that centrifugation with any of several chemical methods (including bleach) is more sensitive, that overnight sedimentation preceded by chemical processing is moresensitive, and that specificity is similar.
Journal ArticleDOI
Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes
TL;DR: It is proposed that the internationally recommended algorithm for the diagnosis of smear-negative pulmonary tuberculosis should be revised to include HIV status, severity of AIDS and tuberculosis, and early use of chest radiography in the decision tree.
Journal ArticleDOI
Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells.
Ann Chapman,Mwansa Munkanta,Katalin A. Wilkinson,Ansar A. Pathan,Katie J. Ewer,Helen Ayles,William H. H. Reece,Alwyn Mwinga,Peter Godfrey-Faussett,Ajit Lalvani +9 more
TL;DR: The ELISPOT assay is more specific, and possibly more sensitive, than PPD-based methods of detecting latent M. tuberculosis infection, and may potentially improve the targeting of isoniazid preventative therapy to HIV-positive individuals with latent tuberculosis infection.
Journal ArticleDOI
Extensively drug-resistant tuberculosis
TL;DR: Clinical manifestations, although variable in different settings and among different strains, have in general shown that XDR tuberculosis is associated with greater morbidity and mortality than non-XDR tuberculosis.
References
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Journal ArticleDOI
Tuberculosis in Patients with Human Immunodeficiency Virus Infection
Diane V. Havlir,Peter F. Barnes +1 more
TL;DR: This work summarizes recent developments in pathogenesis, clinical presentation, treatment, and prevention of tuberculosis in HIV-infected persons over the past several years, as well as the effects of new antiretroviral therapies on antituberculosis regimens.
Journal ArticleDOI
The radiographic appearance of tuberculosis in patients with the acquired immune deficiency syndrome (AIDS) and pre-AIDS.
TL;DR: The medical records and chest radiographs of 23 adult patients with culture-proved tuberculosis were reviewed and acquired immune deficiency syndrome was verified and pulmonary infiltrates that may have been caused by concomitant nontuberculous infection were found.
Journal ArticleDOI
Impact of HIV on tuberculosis in Zambia: a cross sectional study.
Alison M. Elliott,N. Luo,George Tembo,B. Halwiindi,G. Steenbergen,L. Machiels,J. O. M. Pobee,Paul Nunn,Richard J. Hayes,K. P. W. J. Mcadam +9 more
TL;DR: The high prevalence of HIV in patients with tuberculosis suggests that an epidemic of reactivating tuberculosis is arising in those who are infected with HIV, and the redirection of public health priorities towards tuberculosis would focus on a major treatable and preventable complication of the AIDS epidemic.
Journal ArticleDOI
Delayed diagnosis of tuberculosis in patients with human immunodeficiency virus infection.
TL;DR: Delayed therapy of tuberculosis in HIV-infected patients with culture-proven tuberculosis seen at a 1,900-bed general hospital serving a predominantly indigent population in Los Angeles was common and was not due to atypical manifestations of tuberculosis.
Journal Article
The impact of human immunodeficiency virus on presentation and diagnosis of tuberculosis in a cohort study in Zambia.
Alison M. Elliott,B. Halwiindi,Richard J. Hayes,N. Luo,George Tembo,L. Machiels,Chris Bem,G. Steenbergen,J. O. M. Pobee,Paul Nunn +9 more
TL;DR: Two hundred and forty-nine patients with tuberculosis were recruited to a cohort study to investigate the interaction between tuberculosis and HIV in Lusaka, Zambia; findings at presentation are presented here.