Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.
TLDR
The rate of dissociation of 125I-betaNGF from the higher affinity binding site I is accelerated by unlabeled betaNGF under conditions where the occupancy is both increased and decreased.About:
This article is published in Journal of Biological Chemistry.The article was published on 1979-07-10 and is currently open access. It has received 590 citations till now. The article focuses on the topics: Nerve growth factor binding & Dissociation constant.read more
Citations
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The trk proto-oncogene product: a signal transducing receptor for nerve growth factor
TL;DR: Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar.
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The trk proto-oncogene encodes a receptor for nerve growth factor.
TL;DR: The results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor.
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Nerve growth factor signaling, neuroprotection, and neural repair
TL;DR: Expanded roles for NGF that are associated with the dynamically regulated production of NGF and its receptors that begins in development, extends throughout adult life and aging, and involves a surprising variety of neurons, glia, and nonneural cells are considered.
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High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor.
TL;DR: Reconstitution experiments reveal a new growth factor receptor-mediated mechanism of cellular differentiation involving trk and the low-affinity NGF receptor and the tyrosine kinase trk gene product.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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The Attractions of Proteins for Small Molecules and Ions
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The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis
Joseph L. Goldstein,M. S. Brown +1 more
TL;DR: The LDL Pathway is a Vehicle for Normal Human PhySIOLOGY and the PATHOGENESIS of ATHEROSCLEROSIS and its implications for normal human physiology and the pathogenesis of AtherOSCLerosis are discussed.
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The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.
E Rinderknecht,R E Humbel +1 more
TL;DR: The number of differences in amino acid positions between IGF-I and insulins suggests that duplication of the gene of the common ancestor of proinsulin and IGF occurred before the time of appearance of the vertebrates.