Neuromuscular Electrical Stimulation: A New Therapeutic Option for Chronic Diseases Based on Contraction-Induced Myokine Secretion.
Fabian Sanchis-Gomar,Sergio López-López,Carlos Romero-Morales,Nicola Maffulli,Giuseppe Lippi,Helios Pareja-Galeano +5 more
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TLDR
The current evidence supporting NMES as an effective physical exercise substitute for inducing myokine production and its potential applications in health and disease is reviewed.Abstract:
Myokines are peptides known to modulate brain neuroplasticity, adipocyte metabolism, bone mineralization, endothelium repair and cell growth arrest in colon and breast cancer, among other processes. Repeated skeletal muscle contraction induces the production and secretion of myokines, which have a wide range of functions in different tissues and organs. This new role of skeletal muscle as a secretory organ means skeletal muscle contraction could be a key player in the prevention and/or management of chronic disease. However, some individuals are not capable of optimal physical exercise in terms of adequate duration, intensity or muscles involved, and therefore they may be virtually deprived of at least some of the physiological benefits induced by exercise. Neuromuscular electrical stimulation (NMES) is emerging as an effective physical exercise substitute for myokine induction. NMES is safe and efficient and has been shown to improve muscle strength, functional capacity, and quality of life. This alternative exercise modality elicits hypertrophy and neuromuscular adaptations of skeletal muscles. NMES stimulates circulating myokine secretion, promoting a cascade of endocrine, paracrine, and autocrine effects. We review the current evidence supporting NMES as an effective physical exercise substitute for inducing myokine production and its potential applications in health and disease.read more
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Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach.
Zihong He,Ye Tian,Pedro L. Valenzuela,Chuanye Huang,Jiexiu Zhao,Ping Hong,Zilin He,Shuhui Yin,Alejandro Lucia +8 more
TL;DR: The results show no overall differences in the myokine response to HIIT or RT, and it is mostly the individual response of each subject rather than general recommendations on type of training session that must be taken into consideration for maximizing cardiometabolic benefits in the context of personalized exercise prescription.
Journal ArticleDOI
Exercise as a therapy for cancer-induced muscle wasting
TL;DR: This review's primary objective is to summarize the growing body of research examining exercise regulation of cancer cachexia and provide evidence for exercise interactions with established systemic and cellular regulators of cancer-induced muscle wasting.
Journal ArticleDOI
A reconciling hypothesis centred on brain-derived neurotrophic factor to explain neuropsychiatric manifestations in rheumatoid arthritis
Martin Pedard,Aurore Quirié,Anne Tessier,Philippe Garnier,Perle Totoson,Céline Demougeot,Christine Marie +6 more
TL;DR: In this article, a review summarizes the current knowledge on BDNF in RA, proposes possible mechanisms linking RA and brain BDNF deficiency including neuroinflammation, cerebral endothelial dysfunction and sedentary behaviour, and discusses neuromuscular electrical stimulation as an attractive therapeutic option.
Journal ArticleDOI
Muscle-brain communication in pain: The key role of myokines
AMNH Mammalogy,Chen, Yining +1 more
TL;DR: A review of myokines and their role in EIH is presented in this paper , where the authors focus on several myokine proteins and discuss their roles in exercise-induced hypoalgesia.
Journal ArticleDOI
Efficacy and safety of neuromuscular electrical stimulation in the prevention of pressure injuries in critically ill patients: a randomized controlled trial
Miriam Viviane Baron,Paulo Eugênio Silva,Janine Koepp,Janete de Souza Urbanetto,Andres Felipe Mantilla Santamaria,Michele Paula dos Santos,Marcus Vinicius de Mello Pinto,Cristi Lynn Brandenburg,Isabel Cristina Reinheimer,Sonia Carvalho,Mario Bernardes Wagner,T. Miliou,Carlos Eduardo Poli-de-Figueiredo,Bartira Ercília Pinheiro da Costa +13 more
TL;DR: Neuromuscular electrical stimulation (NMES) can increase muscle mass and improve local circulation, potentially reducing the incidence of background pressure injuries (PIs) in critically ill patients as mentioned in this paper .
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