Journal ArticleDOI
Neuropeptide FF analog RF9 is not an antagonist of NPFF receptor and decreases food intake in mice after its central and peripheral administration
Lenka Maletínská,Anežka Tichá,Veronika Nagelová,A. Špolcová,Miroslava Blechová,Tomáš Elbert,Blanka Železná +6 more
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TLDR
In rat pituitary RC-4B/C cells, RF9 did not reverse the phosphorylation of MAPK/ERK1/2 induced by [Tyr(1)]NPFF, casting doubt on claims that RF9 is an NPFF antagonist.About:
This article is published in Brain Research.The article was published on 2013-03-01. It has received 43 citations till now. The article focuses on the topics: Neuropeptide FF & Antagonist.read more
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Journal ArticleDOI
Physiological Roles of Gonadotropin-Inhibitory Hormone Signaling in the Control of Mammalian Reproductive Axis: Studies in the NPFF1 Receptor Null Mouse
Silvia Leon,David Garcia-Galiano,Francisco Ruiz-Pino,Alexia Barroso,Maria Manfredi-Lozano,Antonio Romero-Ruiz,Juan Carlos Roa,María J. Vázquez,Francisco Gaytan,Marion Blomenröhr,Marcel van Duin,Leonor Pinilla,Manuel Tena-Sempere +12 more
TL;DR: The first mouse line with constitutive inactivation of NPFF1R is characterized, and the impact of elimination of GnIH signaling on reproductive parameters and their modulation by metabolic challenges is documented.
Journal ArticleDOI
Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration.
Maletínská L,Nagelová,Alena Ticha,Jana Zemenová,Z. Pirnik,Martina Holubová,A. Špolcová,Barbora Mikulášková,Miroslava Blechová,David Sýkora,Zdeňka Lacinová,Martin Haluzik,Blanka Železná,Jaroslav Kuneš +13 more
TL;DR: Strong anorexigenic and body-weight-reducing effects make lipidized PrRP an attractive candidate for anti-obesity treatment and suggest that the lipidization of PrRP enhances stability and mediates its effect in central nervous system.
Journal ArticleDOI
Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14
Joon S. Kim,Phil W. Brownjohn,Blake S. Dyer,Massimiliano Beltramo,Christopher S. Walker,Debbie L. Hay,Gavin F. Painter,Joel D. A. Tyndall,Greg M. Anderson +8 more
TL;DR: In in vivo tests of hypothalamic-pituitary-adrenal (HPA) axis function, GJ14 completely blocked RFRP-3-induced corticosterone release and neuronal activation in CRH neurons, consistent with the dense expression of NPFF1R in the vicinity ofCRH neurons.
Journal ArticleDOI
Impact of novel palmitoylated prolactin-releasing peptide analogs on metabolic changes in mice with diet-induced obesity.
Veronika Pražienková,Martina Holubová,Helena Pelantová,Martina Bugáňová,Martina Bugáňová,Zdenko Pirnik,Zdenko Pirnik,Barbora Mikulášková,Andrea Popelová,Miroslava Blechová,Martin Haluzik,Blanka Železná,Marek Kuzma,Jaroslav Kuneš,Lenka Maletínská +14 more
TL;DR: The previously reported increase in nicotinamide derivatives in obesity and type 2 diabetes mellitus and the effectiveness of analogs 1 and 2 in the treatment of these disorders were confirmed.
Journal ArticleDOI
Kisspeptin antagonist prevents RF9-induced reproductive changes in female rats
TL;DR: Kisspeptin antagonist, p234, modulates the effects of kisspeptin on reproductive functions and energy balance, whereas RF9 seems to exert only its effects on Reproductive functions by means of GPR54 signaling in female rats.
References
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Journal ArticleDOI
Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF
James A. Bonini,Kenneth A. Jones,Nika Adham,Carlos Forray,Roman Artymyshyn,Margaret M. Durkin,Kelli E. Smith,Joseph A. Tamm,Lakmal W. Boteju,Parul P. Lakhlani,Rita Raddatz,Wen-Jeng Yao,Kristine L. Ogozalek,Noel Boyle,Evguenia V. Kouranova,Yong Quan,Pierre J.-J. Vaysse,John M. Wetzel,Theresa Branchek,Christophe P. G. Gerald,Beth Borowsky +20 more
TL;DR: The localization of mRNA and binding sites of these receptors in the dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei supports a role for NPFF in pain modulation and suggests a potential role forNPFF1 in feeding.
Journal ArticleDOI
Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception.
Qingyun Liu,Xiao-Ming Guan,William J. Martin,Terrence P. McDonald,Michelle K. Clements,Qingping Jiang,Zhizhen Zeng,Marlene A. Jacobson,David L. Williams,Hong Yu,Douglas Bomford,David J. Figueroa,John J. Mallee,Ruiping Wang,Jilly F. Evans,Robert J. Gould,Christopher P. Austin +16 more
TL;DR: The results indicate that the endogenous ligands for FF1 and FF2 are NPVF- and NPFF-derived peptides, respectively, and suggest that theNPVF/FF1 system may be an important part of endogenous anti-opioid mechanism.
Journal ArticleDOI
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia
Frédéric Simonin,Martine Schmitt,Jean-Paul Laulin,Emilie Laboureyras,Jack H. Jhamandas,David MacTavish,Audrey Matifas,Catherine Mollereau,Patrick Laurent,Marc Parmentier,Brigitte L. Kieffer,Jean-Jacques Bourguignon,Guy Simonnet +12 more
TL;DR: The discovery of a potent and selective NPFF receptor antagonist, RF9, that can be administered systemically and indicate that NPFF receptors are part of a bona fide antiopioid system and that selective antagonists of these receptors could represent useful therapeutic agents for improving the efficacy of opioids in chronic pain treatment.
Journal ArticleDOI
The expanding family of -RFamide peptides and their effects on feeding behaviour.
TL;DR: One of the emerging themes from recent research is that these peptides are involved in control of feeding behaviour both in invertebrates and in vertebrates, which would seem to be a remarkable example of conservation of chemical structure and biological function throughout nervous system evolution.
Journal ArticleDOI
The opioid control of lh and fsh release: effects of a met‐enkephalin analogue and naloxone
Ashley B. Grossman,P. J. A. Moult,R. C. Gaillard,G. Delitala,W. D. Toff,Lesley H. Rees,G. M. Besser +6 more
TL;DR: The results suggest that met‐enkephalin‐like opioid peptides exert a tonic inhibitory control of LH release in both menopausal and young subjects of both sexes, and involves modulation of pulsatile LHRH release.
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