Journal ArticleDOI
Neurophysiological effects in cortico-basal ganglia-thalamic circuits of antidyskinetic treatment with 5-HT1A receptor biased agonists
Ivani Brys,Pär Halje,Robson Scheffer-Teixeira,Mark A. Varney,Adrian Newman-Tancredi,Per Petersson,Per Petersson +6 more
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TLDR
Investigation of changes in the spectral contents of local field potentials in cortico‐basal ganglia‐thalamic circuits following treatment with this novel group of 5‐HT1A agonists suggests that the common antidyskinetic effects of these drugs may be chiefly attributable to a reversal of the brain state characterized by 80Hz gamma oscillations.About:
This article is published in Experimental Neurology.The article was published on 2018-04-01. It has received 22 citations till now. The article focuses on the topics: Dyskinesia & Parkinson's disease.read more
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Journal ArticleDOI
Emerging Immunotherapies for Parkinson Disease
Samis Zella,Judith Metzdorf,Emine Ciftci,Friederike Ostendorf,Siegfried Muhlack,Ralf Gold,Lars Tönges +6 more
TL;DR: The pathomechanistic role of alpha-synuclein and its influence on the surrounding cellular environment are analyzed with a strong focus on immune responses and neuroinflammation and give reason to hope that a causal therapy of Parkinson disease could be possible in the foreseeable future.
Journal ArticleDOI
The selective 5-HT1A receptor agonist, NLX-112, exerts anti-dyskinetic and anti-parkinsonian-like effects in MPTP-treated marmosets
Ria Fisher,Atsuko Hikima,Rebecca Morris,Michael J. Jackson,Sarah Rose,Mark A. Varney,Ronan Depoortère,Adrian Newman-Tancredi +7 more
TL;DR: It is shown that NLX-112 has anti-LID activity at the doses tested as well as reducing motor disability, suggesting that it may have motor facilitation effects of its own.
Journal ArticleDOI
Oscillations in cortico-basal ganglia circuits: implications for Parkinson’s disease and other neurologic and psychiatric conditions
Pär Halje,Ivani Brys,Juan J. Mariman,Juan J. Mariman,Claudio Da Cunha,Romulo Fuentes,Per Petersson,Per Petersson +7 more
TL;DR: Experimental support for the hypothesis that excessive synchronization of neuronal activity may be a pathophysiological mechanism involved in a wide range of neurologic and psychiatric conditions is reviewed primarily in relation to Parkinson's disease, but also to dystonia, essential tremor, epilepsy and psychosis/schizophrenia.
Journal ArticleDOI
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders.
TL;DR: In this article, a new generation of highly selective, efficacious and druggable biased agonists have been identified which exhibit increased affinity at 5-HT1A receptors and new profiles of cellular signaling bias, notably for β-arrestin recruitment versus pERK.
Journal ArticleDOI
Translating biased agonists from molecules to medications: Serotonin 5-HT1A receptor functional selectivity for CNS disorders
TL;DR: In this paper , a new generation of highly selective, efficacious and druggable 5-HT1A receptor biased agonists have been identified, which have shown differential properties for G-protein signaling, cellular signaling, electrophysiological effects, neurotransmitter release, neuroimaging by PET and pharmacoMRI, and behavioral tests of mood, motor activity and side effects.
References
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Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
TL;DR: A plethora of studies will be reviewed on the involvement of long-distance neuronal coherence in cognitive functions such as multisensory integration, working memory, and selective attention, and implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism.
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Measuring Phase-Amplitude Coupling Between Neuronal Oscillations of Different Frequencies
TL;DR: This work presents a new measure for assessing phase-amplitude CFC, defined as an adaptation of the Kullback-Leibler distance-a function that is used to infer the distance between two distributions-and calculates how much an empirical amplitude distribution-like function over phase bins deviates from the uniform distribution.
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