Open Access
New Markers of Acute Kidney Injury: Giant Leaps and Baby Steps
Zoltan H. Endre,John W. Pickering +1 more
- Vol. 32, Iss: 2, pp 121-124
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TLDR
Sufficient new biomarkers have been discovered and evaluated to expect that not one biomarker but a panel of biomarkers applied according to phase of injury, baseline renal function and comorbidities will be necessary for the early diagnosis of acute kidney injury.Abstract:
Treatment of acute kidney injury has been hampered by the inability of a creatinine-based diagnosis to allow clinicians to intervene with timely treatments aimed at preventing further development of the disease to the point where renal replacement therapy is necessary or death occurs. Novel biomarkers of injury have been touted as the tool by which early detection can occur and, on that basis, novel treatments can be developed and delivered early in the disease process. Sufficient new biomarkers have been discovered and evaluated to expect that not one biomarker but a panel of biomarkers applied according to phase of injury, baseline renal function and comorbidities will be necessary for the early diagnosis of acute kidney injury. Issues of validation of these biomarkers remain, particularly in heterogeneous populations of critically ill patients. Nevertheless, we are rapidly moving towards an era where the diagnosis of acute kidney injury will be proactive rather than by the traditional diagnosis of exclusion.read more
Citations
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Septic AKI in ICU patients. diagnosis, pathophysiology, and treatment type, dosing, and timing: a comprehensive review of recent and future developments
Patrick M. Honore,Rita Jacobs,Olivier Joannes-Boyau,Jouke De Regt,Willem Boer,Elisabeth De Waele,Vincent Collin,Herbert D. Spapen +7 more
TL;DR: In this paper, a large-scale introduction of citrate as an anticoagulant most likely will change CRRT management in intensive care units (ICU), because it not only significantly increases filter lifespan but also better preserves filter porosity.
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Urinary expression of novel tissue markers of kidney injury after ureteroscopy, shockwave lithotripsy, and in normal healthy controls.
Nader Fahmy,Alp Sener,Venkata S. Sabbisetti,Linda Nott,R. Michael Lang,Blayne Welk,Carlos E. Méndez-Probst,Roderick A. MacPhee,Susan VanEerdewijk,Peter A. Cadieux,Joseph V. Bonventre,Hassan Razvi +11 more
TL;DR: Kim-1 and NAG levels significantly increased post-SWL treatment suggesting a potential role for these urinary markers in identifying patients at higher risk of tissue injury.
Journal ArticleDOI
Biomarkers for early diagnosis of AKI in the ICU: ready for prime time use at the bedside?
Patrick M. Honore,Rita Jacobs,Olivier Joannes-Boyau,Lies Verfaillie,Jouke De Regt,Viola Van Gorp,Elisabeth De Waele,Willem Boer,Vincent Collin,Herbert D. Spapen +9 more
TL;DR: In general, kidney biomarkers may aid to direct early aggressive treatment strategies for AKI thereby decreasing the associated high mortality, and “Kits” containing a combination of established biomarkers, in conjunction with measured glomerular filtration rate, may enhance diagnostic and prognostic accuracy in the future.
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Prediction of the renal replacement therapy requirement in mechanically ventilated critically ill patients by combining biomarkers for glomerular filtration and tubular damage
Chrysoula Pipili,Sophia Ioannidou,Elli-Sophia Tripodaki,Maria Parisi,Evangelia Douka,Ioannis Vasileiadis,Michael Joannidis,Serafim Nanas +7 more
TL;DR: Specific markers of kidney dysfunction and of kidney damage can be successfully combined to increase the prognostic capability for RRT initiation.
Journal ArticleDOI
Kidney Biomarkers and Decline in eGFR in Patients with Type 2 Diabetes
Katherine G. Garlo,William B. White,George L. Bakris,Faiez Zannad,Craig A. Wilson,Stuart Kupfer,Muthiah Vaduganathan,David A. Morrow,Christopher P. Cannon,David M. Charytan +9 more
TL;DR: The addition of cystatin C or biomarkers of tubular injury did not meaningfully improve the prediction of eGFR decline beyond common clinical factors and routine laboratory data in a large cohort of patients with type 2 diabetes and recent acute coronary syndrome.
References
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