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New trends for metal complexes with anticancer activity.

Pieter C. A. Bruijnincx, +1 more
- 01 Apr 2008 - 
- Vol. 12, Iss: 2, pp 197-206
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TLDR
Recent trends in the field include the more selective delivery and/or activation of cisplatin-related prodrugs and the discovery of new non-covalent interactions with the classical target, DNA.
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This article is published in Current Opinion in Chemical Biology.The article was published on 2008-04-01 and is currently open access. It has received 1164 citations till now.

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Advances in copper complexes as anticancer agents.

Carlo Santini, +5 more
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Ingo Ott
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The Medicinal Applications of Imidazolium Carbene Metal Complexes

Khadijah M. Hindi, +4 more
- 06 Jul 2009 - 
TL;DR: This review will discuss in detail the medicinal applications of various transition metal-NHC complexes including silver, gold, rhodium, ruthenium, and palladium along with proposed mechanisms of action to suppress the bacterial growth or proliferation of tumor cells will be discussed.
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Metal N-heterocyclic carbene complexes as potential antitumor metallodrugs

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References
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Journal ArticleDOI

Direct cellular responses to platinum-induced DNA damage

Yongwon Jung, +1 more
- 25 Apr 2007 - 
Journal ArticleDOI

Metals in Medicine

Zijian Guo, +1 more
- 01 Jun 1999 - 
TL;DR: In the fight against cancer cisplatin, one of the world's best selling anticancer drugs, is being joined by other platinum, titanium, and ruthenium complexes, and metal-targeted organic agents show exciting clinical potential.
Journal ArticleDOI

In Vitro and in Vivo Evaluation of Ruthenium(II)−Arene PTA Complexes

Claudine Scolaro, +8 more
- 21 May 2005 - 
TL;DR: Results show that these ruthenium(II)-arene complexes can reduce the growth of lung metastases in CBA mice bearing the MCa mammary carcinoma in the absence of a corresponding action at the site of primary tumor growth.
Journal ArticleDOI

Metal-based antitumour drugs in the post genomic era.

Paul J. Dyson, +1 more
- 11 Apr 2006 - 
TL;DR: What the future holds for metal-based drugs, in particular anti-metastasis drugs,In these enlightened times of the post genomic era is discussed.
Journal ArticleDOI

Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes

Yaw Kai Yan, +3 more
- 27 Sep 2005 - 
TL;DR: Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reactions of Ru(II) arene complexes with biomolecules can be achieved.
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Frequently Asked Questions (1)
Q1. What are the contributions in "New trends for metal complexes with anticancer activity" ?

Recent trends in the field are discussed in this review. The use of the metal as scaffold rather than reactive centre and the departure from the cisplatin paradigm of activity towards a more targeted, cancer cell-specific approach, a major trend, are discussed as well.