Nicotine Accelerates Atherosclerosis in Apolipoprotein E–Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells
Chen Wang,Han Chen,Wei Zhu,Yinchuan Xu,Mingfei Liu,Lianlian Zhu,Fan Yang,Ling Zhang,Xianbao Liu,Zhiwei Zhong,Jing Zhao,Jun Jiang,Meixiang Xiang,Hong Yu,Xinyang Hu,Hong Lu,Jian-an Wang +16 more
TLDR
Activation of &agr;7 nicotinic acetylcholine receptor on MCs is a mechanism by which nicotine enhances atherosclerosis.Abstract:
Objective—Cigarette smoking is an independent risk factor for atherosclerosis. Nicotine, the addictive component of cigarettes, induces mast cell (MC) release and contributes to atherogenesis. The ...read more
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Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.
Xianxian Wu,Xianxian Wu,Haiying Zhang,Wei Qi,Ying Zhang,Jiamin Li,Zhange Li,Yuan Lin,Xue Bai,Xin Liu,Xiaohui Chen,Huan Yang,Chaoqian Xu,Yong Zhang,Yong Zhang,Baofeng Yang,Baofeng Yang +16 more
TL;DR: It is found that nicotine resulted in larger atherosclerotic plaques and secretion of inflammatory cytokines in ApoE−/− mice fed with a high-fat diet (HFD) and pyroptosis is likely a cellular mechanism for the pro-atherosclerosis property of nicotine.
Journal ArticleDOI
Myocardial Infarction—From Atherosclerosis to Thrombosis
Jathushan Palasubramaniam,Jathushan Palasubramaniam,Jathushan Palasubramaniam,Xiaowei Wang,Xiaowei Wang,Karlheinz Peter,Karlheinz Peter,Karlheinz Peter +7 more
Journal ArticleDOI
Chronic intermittent electronic cigarette exposure induces cardiac dysfunction and atherosclerosis in apolipoprotein-E knockout mice.
Jorge Espinoza-Derout,Kamrul Hasan,Xuesi M. Shao,Xuesi M. Shao,Maria C. Jordan,Carl Sims,Desean L. Lee,Satyesh K. Sinha,Satyesh K. Sinha,Zena Simmons,Norma Mtume,Yanjun Liu,Yanjun Liu,Kenneth P. Roos,Amiya P. Sinha-Hikim,Amiya P. Sinha-Hikim,Theodore C. Friedman,Theodore C. Friedman +17 more
TL;DR: Adverse effects of e-cigarettes on cardiac function in mice are demonstrated by increased oxidative stress and mitochondrial DNA mutations and increased atherosclerotic lesions compared to saline aerosol-treated mice.
Journal ArticleDOI
Nicotine-mediated autophagy of vascular smooth muscle cell accelerates atherosclerosis via nAChRs/ROS/NF-κB signaling pathway
TL;DR: Nicotine-induced autophagy promotes the phenotype switching of VSMCs and accelerates atherosclerosis, which is partly mediated by the nAChRs/ROS/NF-κB signaling pathway.
Journal ArticleDOI
Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation.
Fan Yang,Rongrong Wu,Zhi Jiang,Jinghai Chen,Jinliang Nan,Sheng-an Su,Na Zhang,Chen Wang,Jing Zhao,Cheng Ni,Yingchao Wang,Wangxing Hu,Zhiru Zeng,Keyang Zhu,Xianbao Liu,Xinyang Hu,Wei Zhu,Hong Yu,Jinyu Huang,Jian-an Wang +19 more
TL;DR: In the hostile microenvironment caused by MI, leptin can maintain the mitochondrial integrity and prolong the survival of hMSCs; leptin-mediated mitochondrial integrity requires phosphorylation of GSK3 as a prerequisite for ubiquitination-depended degradation of OMA1 and attenuation of long-OPA1 cleavage.
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