Journal ArticleDOI
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.
TLDR
The synthesis of the dicyclohexyl analogues of DPEA and related compounds were tested as inhibitors of [(3)H]MK-801 binding to rat brain membranes and exhibited stereospecific sensitivity to the modulator spermine.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2009-05-01. It has received 34 citations till now. The article focuses on the topics: Channel blocker.read more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.
Hamilton Morris,Jason Wallach +1 more
TL;DR: The first complete portrait of this underground market is presented along with the relevant legal, technological, and scientific developments which have driven its evolution.
Journal ArticleDOI
Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products
TL;DR: In this article, 19 newly distributed designer drugs were identified in 104 products in an ongoing survey of illegal products in Japan from November 2013 to May 2014, and a total of 33 designer drugs including compounds 1-19 were detected in the 104 illegal products, in 60 different combination patterns.
Journal ArticleDOI
Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
Gabriele Pupo,Anna Chiara Vicini,David M. H. Ascough,Francesco Ibba,Kirsten E. Christensen,Amber L. Thompson,John M. Brown,Robert S. Paton,Robert S. Paton,Véronique Gouverneur +9 more
TL;DR: It is demonstrated that hydrogen bonding phase-transfer catalysis with KF provides access to valuable β-fluoroamines in high yields and enantioselectivities.
References
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Journal ArticleDOI
Channel blockers acting at N-methyl-D-aspartate receptors: differential effects of mutations in the vestibule and ion channel pore.
Keiko Kashiwagi,Takashi Masuko,Christopher D. Nguyen,Tomoko Kuno,Ikuko Tanaka,Kazuei Igarashi,Keith Williams +6 more
TL;DR: The effects of mutations in and around the membrane-spanning and pore-forming regions of NMDA receptor subunits were studied with three blockers, MK-801, memantine, and TB-3-4, using recombinant NMDA receptors expressed in Xenopus laevis oocytes.
Journal ArticleDOI
Block and Modulation of N-Methyl-D-Aspartate Receptors by Polyamines and Protons: Role of Amino Acid Residues in the Transmembrane and Pore-Forming Regions of NR1 and NR2 Subunits
TL;DR: It is suggested that at least parts of the M1 and M3 segments contribute to the pore or vestibule of the NMDA channel and that a tryptophan residue at position W607 in the M2 region of NR2B greatly reduced block by N1-DnsSpm, and N1 to permeate channels containing this mutation.
Journal Article
Differences in degree of trapping of low-affinity uncompetitive N-methyl-D-aspartic acid receptor antagonists with similar kinetics of block.
TL;DR: Differences in the degree of trapping exist among use-dependent NMDA receptor antagonists even when on and off rates are similar, and these differences are correlated with measures of therapeutic index.
Journal ArticleDOI
Reactions of relevance to the chemistry of aminoglycoside antibiotics. Part 7. Conversion of thiocarbonates into deoxy-sugars
TL;DR: Radical-initiated reduction of five- or six-membered ring thiocarbonates, followed by alkaline hydrolysis, affords a convenient synthesis of 2, 3, 4, and 5-deoxy-sugars, and regiospecificity of the reaction complements the recently developed synthesis of 6- deoxy-Sugars by ring opening of the same thiOCarbonates with methyl iodide.
Journal ArticleDOI
Direct 1H NMR assay of the enantiomeric composition of amines and β-amino alcohols using o-acetyl mandelic acid as a chiral solvating agent
TL;DR: The chiral solvating agent (R )-O-Acetyl Mandelic Acid (ROAM) is an effective agent for the direct 1H NMR assay of the enantiomeric composition of amines and amino-alcohols as discussed by the authors.
Related Papers (5)
From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.
Hamilton Morris,Jason Wallach +1 more