Journal ArticleDOI
NMDA receptor affinities of 1,2-diphenylethylamine and 1-(1,2-diphenylethyl)piperidine enantiomers and of related compounds.
TLDR
The synthesis of the dicyclohexyl analogues of DPEA and related compounds were tested as inhibitors of [(3)H]MK-801 binding to rat brain membranes and exhibited stereospecific sensitivity to the modulator spermine.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2009-05-01. It has received 34 citations till now. The article focuses on the topics: Channel blocker.read more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.
Hamilton Morris,Jason Wallach +1 more
TL;DR: The first complete portrait of this underground market is presented along with the relevant legal, technological, and scientific developments which have driven its evolution.
Journal ArticleDOI
Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products
TL;DR: In this article, 19 newly distributed designer drugs were identified in 104 products in an ongoing survey of illegal products in Japan from November 2013 to May 2014, and a total of 33 designer drugs including compounds 1-19 were detected in the 104 illegal products, in 60 different combination patterns.
Journal ArticleDOI
Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines
Gabriele Pupo,Anna Chiara Vicini,David M. H. Ascough,Francesco Ibba,Kirsten E. Christensen,Amber L. Thompson,John M. Brown,Robert S. Paton,Robert S. Paton,Véronique Gouverneur +9 more
TL;DR: It is demonstrated that hydrogen bonding phase-transfer catalysis with KF provides access to valuable β-fluoroamines in high yields and enantioselectivities.
References
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Journal ArticleDOI
Subunit arrangement and function in NMDA receptors
TL;DR: In this article, crystal structures of the ligand-binding core of NR2A with glutamate and that of the NR1-NR2A heterodimer with glycine and glutamate were reported.
Journal ArticleDOI
Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse.
TL;DR: This review summarizes existing hypotheses on the mechanism of action (MOA) of memantine in an attempt to understand how the accepted interaction with NMDA receptors could allow memantine to provide both neuroprotection and reverse deficits in learning/memory by the same MOA.
Journal ArticleDOI
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core
Hiroyasu Furukawa,Eric Gouaux +1 more
TL;DR: The cocrystal structures of the NR1 S1S2 ligand‐binding core with the agonists glycine and D‐serine (DS), the partial agonist D‐cycloserine (DCS) and the antagonist 5,7‐dichlorokynurenic acid (DCKA) are described.
Journal ArticleDOI
Alternatively spliced isoforms of the NMDARI receptor subunit.
TL;DR: The finding of cell-specific expression and developmental regulation of NRI splice variants, and of the NR2 subunits, provides an explanation for the diversity of properties of NMDA receptors in different neuronal populations.
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From PCP to MXE: a comprehensive review of the non-medical use of dissociative drugs.
Hamilton Morris,Jason Wallach +1 more