Journal ArticleDOI
NMDA receptors and memory encoding
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TLDR
How my then interest in long-term potentiation (LTP) as a model of memory enabled me to recognise the importance of Collingridge et al.'s discovery is laid out - and how the idea that NMDA receptor activation is essential for memory encoding, though not for storage, took time to develop and to be accepted.About:
This article is published in Neuropharmacology.The article was published on 2013-11-01. It has received 234 citations till now. The article focuses on the topics: Synaptic plasticity & Long-term potentiation.read more
Citations
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The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis.
Michael D. Scofield,Jasper A. Heinsbroek,Cassandra D. Gipson,Yonatan M. Kupchik,Sade Spencer,Alexander C.W. Smith,Douglas Roberts-Wolfe,P. W. Kalivas +7 more
TL;DR: A review of the literature describing how synaptic plasticity in the accumbens is altered after exposure to drugs of abuse and withdrawal and also how pharmacological manipulation of glutamate systems in the Accumbens can inhibit drug seeking in the laboratory setting is provided.
Journal ArticleDOI
Structure, function, and allosteric modulation of NMDA receptors.
Kasper B. Hansen,Feng Yi,Riley E. Perszyk,Hiro Furukawa,Lonnie P. Wollmuth,Alasdair J. Gibb,Stephen F. Traynelis +6 more
TL;DR: The relationship between NMDA receptor structure and function is reviewed with an emphasis on emerging atomic resolution structures, which begin to explain unique features of this receptor.
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CaMKII: claiming center stage in postsynaptic function and organization.
TL;DR: Novel molecular and functional insight is reviewed into how CaMKII supports synaptic function by reviewing the multilayered and complex nature ofCaMKII's involvement in synaptic regulation.
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Replay Comes of Age
TL;DR: Hippocampal place cells take part in sequenced patterns of reactivation after behavioral experience, known as replay, and a focus on the phenomenology of replay is focused on.
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GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
Olivia A. Shipton,Ole Paulsen +1 more
TL;DR: It is concluded that the presence of GluN2B subunit-containing NMDARs at the postsynaptic density might be a necessary, though not a sufficient, condition for the strengthening of individual synapses.
References
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Upstairs/downstairs revisited: spatial pretraining-induced rescue of normal spatial learning during selective blockade of hippocampal N-methyl-d-aspartate receptors.
TL;DR: In naïve rats, D‐AP5 caused a dose‐related impairment in spatial reference memory acquisition that was significant at the lowest 5 nm/h infusion concentration, and in pretrained rats, the dose–response function was shifted such that, in watermaze 2, spatial learning was normal at this low concentration, with a deficit at higher infusion concentrations.
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The cellular mechanisms of memory are modified by experience.
TL;DR: Using contextual fear conditioning in mice, it is found that NMDAR-independent learning is only observed when animals are trained on the same behavioral task and initial learning is successfully encoded into long-term memory.
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Anesthetic neurotoxicity: a difficult dragon to slay.
TL;DR: This issue of Anesthesia & Analgesia shows that children exposed to anesthesia and surgery have a much greater likelihood of being diagnosed with a developmental or behavioral disorder than do unexposed children, but that within a matched twin pair, in which one sibling was exposed to surgery and the other was not, there was no greater risk of an adverse outcome.