Journal ArticleDOI
NMDA receptors and memory encoding
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TLDR
How my then interest in long-term potentiation (LTP) as a model of memory enabled me to recognise the importance of Collingridge et al.'s discovery is laid out - and how the idea that NMDA receptor activation is essential for memory encoding, though not for storage, took time to develop and to be accepted.About:
This article is published in Neuropharmacology.The article was published on 2013-11-01. It has received 234 citations till now. The article focuses on the topics: Synaptic plasticity & Long-term potentiation.read more
Citations
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Different components of conditioned food aversion memory.
TL;DR: The results suggest that the maintenance of a conditioned food aversion involves two different components with variable dynamics, which could be characterized by memory strengthening over time and involve N-methyl-D-aspartate receptors and protein synthesis reconsolidation at early, but not late, training stages.
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Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network
Eva Ploux,Valentine Bouet,Inna Radzishevsky,Herman Wolosker,Thomas Freret,Jean-Marie Billard +5 more
TL;DR: Results indicate that depletion of endogenous D-serine caused a reduced inhibitory activity in CA1 hippocampal networks, altering the excitatory/inhibitory balance, which contributes to preserve functional plasticity at synapses and to maintain related cognitive abilities.
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Mammillary body regulates state-dependent fear by alternating cortical oscillations
Jun Jiang,Guang-Yu Wang,Guang-Yu Wang,Wenhan Luo,Wenhan Luo,Hong Xie,Ji-Song Guan,Ji-Song Guan,Ji-Song Guan +8 more
TL;DR: It is found that MK-801 enhanced delta oscillations in awake mice, representing a drug-induced brain state, in which fear memory could only be successfully retrieved when the same drug condition was presented, shining light on the neural mechanism underlying the fluctuation of memory retrieval and the role of MB in memory encoding and recall.
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Asymmetric Synthesis of the Two Enantiomers of β-Phosphorus-containing α-Amino Acids via Hydrophosphinylation and Hydrophosphonylation of Chiral Ni(II)-Complexes
Yoshinori Tokairin,Hiroyuki Konno,Angéline Noireau,Caroline West,Hiroki Moriwaki,Vadim A. Soloshonok,Vadim A. Soloshonok,Cyril Nicolas,Isabelle Gillaizeau +8 more
TL;DR: In this paper, a new approach for the asymmetric synthesis of β-phosphorus-containing α-amino acids was developed via the addition of secondary phosphine oxides and dialkyl phosphites to chiral Ni(II)-complexes of a dehydroalanine-Schiff base.
Journal ArticleDOI
Design and Synthesis of Novel and Selective Glycine Transporter-1 (GlyT1) Inhibitors with Memory Enhancing Properties
Vincent J. Santora,Theresa A. Almos,Richard Barido,Jillian Basinger,Chris L. Bellows,Brett C. Bookser,J. Guy Breitenbucher,Nicola J. Broadbent,Clifford Cabebe,Chih-Kun Chai,Mi Chen,Stephine Chow,De Michael Chung,Lindsay Crickard,Anne Danks,Graeme Freestone,Dany Gitnick,Varsha Gupta,Christine Hoffmaster,Andrew Richard Hudson,Alan P. Kaplan,Michael R. Kennedy,Dong Lee,James T. Limberis,Kiev S. Ly,Chi Ching Mak,Brittany Masatsugu,Andrew Morse,Jim Na,David Neul,John Nikpur,Marco Peters,Robert E. Petroski,Joel Renick,Kristen Sebring,Samantha Sevidal,Ali Tabatabaei,Jenny Wen,Yingzhuo Yan,Zachary W. Yoder,Douglas Zook +40 more
TL;DR: A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles amides (21-50) with good in vitro potency and optimization produced several compounds with promising pharmacokinetic profiles.
References
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Neural networks and physical systems with emergent collective computational abilities
TL;DR: A model of a system having a large number of simple equivalent components, based on aspects of neurobiology but readily adapted to integrated circuits, produces a content-addressable memory which correctly yields an entire memory from any subpart of sufficient size.
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Place navigation impaired in rats with hippocampal lesions.
TL;DR: It is reported that, in addition to a spatial discrimination impairment, total hippocampal lesions also cause a profound and lasting placenavigational impairment that can be dissociated from correlated motor, motivational and reinforcement aspects of the procedure.
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Neural computation of decisions in optimization problems
John J. Hopfield,David W. Tank +1 more
TL;DR: Results of computer simulations of a network designed to solve a difficult but well-defined optimization problem-the Traveling-Salesman Problem-are presented and used to illustrate the computational power of the networks.
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Magnesium gates glutamate-activated channels in mouse central neurones
TL;DR: The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.
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Selective impairment of learning and blockade of long-term potentiation by an N -methyl-D-aspartate receptor antagonist, AP5
TL;DR: This article showed that chronic intraventricular infusion of D,L-AP5 causes a selective impairment of place learning, which is highly sensitive to hippocampal damage, without affecting visual discrimination learning.