Journal ArticleDOI
NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging
TLDR
Ga-radiolabelling and stability data of 1,4,7-triazacyclononane-1,4-diacetic acid-7-p-hydroxyphenyl-acetic acid are reported, versatile bifunctional chelators with potential for molecular imaging.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2008-10-15. It has received 55 citations till now. The article focuses on the topics: Bifunctional.read more
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Prospective of ⁶⁸Ga-radiopharmaceutical development.
TL;DR: The future development of the 68Ga-radiopharmaceuticals must be put in the context of several aspects such as role of PET in nuclear medicine, unmet medical needs, identification of new biomarkers, targets and corresponding ligands, production and availability of 68Ga, automation of the radiopharm pharmaceutical production, progress of positron emission tomography technologies and image analysis methodologies.
Journal ArticleDOI
Molecular imaging targeting peptide receptors.
TL;DR: This review summarizes the development of radiolabeled probes for peptide receptor imaging since the emergence of the technology with a particular focus on peptide radiopharmaceuticals developed during the last 5 years, and highlights the different factors which are decisive during the process of tracer development and evaluation.
Journal ArticleDOI
The renaissance of the ⁶⁸Ge/⁶⁸Ga radionuclide generator initiates new developments in ⁶⁸Ga radiopharmaceutical chemistry.
Frank Roesch,Patrick J. Riss +1 more
TL;DR: Today, one may expect that the ⁶⁸Ge/⁶⁰Ga radionuclide generator systems could contribute to and facilitate the clinical impact of nuclear medicine diagnoses for PET in a dimension comparable to the established ⁹⁹Mo/⁵⁹(m)Tc generator system for SPECT.
Journal ArticleDOI
The synthesis and application of polyamino polycarboxylic bifunctional chelating agents
TL;DR: Of all the ligands reported so far, those based on a polyamino polycarboxylic structure are most efficient and are widely employed for the chelation of metal ions.
Journal ArticleDOI
A Triazacyclononane‐Based Bifunctional Phosphinate Ligand for the Preparation of Multimeric 68Ga Tracers for Positron Emission Tomography
Johannes Notni,Johannes Notni,Petr Hermann,Jana Havlíčková,Jan Kotek,Vojtěch Kubíček,Jan Plutnar,Natalia Loktionova,Patrick J. Riss,Frank Rösch,Ivan Lukeš +10 more
TL;DR: For application in positron emission tomography (PET), PrP9, a N,N',N''-trisubstituted triazacyclononane with methyl(2-carboxyethyl)phosphinic acid pendant arms, was developed as (68)Ga(3+) complexing agent, which for the first time can be directly used for labeling purposes.
References
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Simple Method for the Esterification of Carboxylic Acids
B. Neises,Wolfgang Steglich +1 more
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Nitrogen Analogs of Crown Ethers
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Processing of Generator-Produced 68Ga for Medical Application
Konstantin Zhernosekov,Dimitry Filosofov,Richard P. Baum,Peter Aschoff,Heiner Bihl,Anatoli A. Razbash,Markus Jahn,Mark Jennewein,Frank Rösch +8 more
TL;DR: In this article, an efficient post-eluate processing of generator-derived 68Ge/68Ga eluates, including the labeling and purification of biomolecules, is presented.
Journal ArticleDOI
NODAGATOC, a new chelator-coupled somatostatin analogue labeled with [67/68Ga] and [111In] for SPECT, PET, and targeted therapeutic applications of somatostatin receptor (hsst2) expressing tumors
Klaus Peter Eisenwiener,M. I. M. Prata,I. Buschmann,Han Wen Zhang,A. C. Santos,Sandra Wenger,Jean-Claude Reubi,Helmut R. Mäcke +7 more
TL;DR: A monoreactive NOTA (1,4,7-triazacyclonononane-1, 4, 7-triacetic acid) derived prochelator (1-(1-carboxy-3-carbo-tert-butoxypropyl)-4, 7-(carbo -tert -butoxymethyl)- 1, 4, 7, 7, triazacycyclononanes (NODAGA(tBu)(3))) was synthesized in five steps with an overall yield of 21% as discussed by the authors
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Neuere Methoden der präparativen organischen Chemie II 14. N-Bromsuccinimid, Eigenschaften und Reaktionsweisen Studien zum Ablauf der Substitution XV†
L. Horner,E. H. Winkelmann +1 more
TL;DR: In this paper, the Moglichkeiten, die das N-Brom-succinimid bietet, zunachst allgemein an zahlreichen Verbindungsklassen gezeigt und anschliesend praparative Arbeitsbeispiele mitgeteilt.