Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation.
Fabiola Paciello,Anna Pisani,Rolando Rolesi,Vincent Escarrat,Jacopo Galli,Gaetano Paludetti,Claudio Grassi,Diana Troiani,Anna Rita Fetoni +8 more
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TLDR
In this article, the authors used an in vivo model of noise-induced hearing loss to investigate how oxidative stress and inflammation participate in cochlear dysfunction through PPAR signaling pathways.Abstract:
The cross-talk between oxidative stress and inflammation seems to play a key role in noise-induced hearing loss. Several studies have addressed the role of PPAR receptors in mediating antioxidant and anti-inflammatory effects and, although its protective activity has been demonstrated in several tissues, less is known about how PPARs could be involved in cochlear dysfunction induced by noise exposure. In this study, we used an in vivo model of noise-induced hearing loss to investigate how oxidative stress and inflammation participate in cochlear dysfunction through PPAR signaling pathways. Specifically, we found a progressive decrease in PPAR expression in the cochlea after acoustic trauma, paralleled by an increase in oxidative stress and inflammation. By comparing an antioxidant (Q-ter) and an anti-inflammatory (Anakinra) treatment, we demonstrated that oxidative stress is the primary element of damage in noise-induced cochlear injury and that increased inflammation can be considered a consequence of PPAR down-regulation induced by ROS production. Indeed, by decreasing oxidative stress, PPARs returned to control values, reactivating the negative control on inflammation in a feedback loop.read more
Citations
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Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review
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TL;DR: The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals, and the assessment of new pharmacological options, novel bioactive molecules, nanoparticles, stem cells, and gene therapy.
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Redox Imbalance as a Common Pathogenic Factor Linking Hearing Loss and Cognitive Decline
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Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss
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TL;DR: Overall, the data demonstrate that Cx30 deletion can be considered a genetic risk factor for ARHL, making cochlear structures more susceptible to aging processes.
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Hearing Research Special Issue: Mitochondrial Function and Dysfunction in the Inner Ear
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TL;DR: In this paper , the authors provide an overview of the current knowledge on the role of mitochondrial dysfunction and oxidative stress in the development of sensorineural hearing loss caused by genetic mutations, aging, exposure to excessive noise, and ototoxic drugs.
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Role of mitochondrial dysfunction and oxidative stress in sensorineural hearing loss
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TL;DR: In this article , the authors provide an overview of the current knowledge on the role of mitochondrial dysfunction and oxidative stress in the development of sensorineural hearing loss caused by genetic mutations, aging, exposure to excessive noise, and ototoxic drugs.
References
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Journal ArticleDOI
Anti-oxidant and anti-inflammatory effects of caffeic acid: in vivo evidences in a model of noise-induced hearing loss.
Fabiola Paciello,Antonella Di Pino,Rolando Rolesi,Diana Troiani,Gaetano Paludetti,Claudio Grassi,Anna Rita Fetoni +6 more
TL;DR: It is demonstrated that the supplementation of polyphenol CA can be considered a valid therapeutic strategy for attenuating noise-induced hearing loss and cochlear damage, targeting both inflammatory signalling and co chlear redox balance.
Journal ArticleDOI
Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea.
Tetsuya Nakamoto,Takefumi Mikuriya,Kazuma Sugahara,Yoshinobu Hirose,Tomoko Hashimoto,Hiroaki Shimogori,Ryosuke Takii,Akira Nakai,Hiroshi Yamashita +8 more
TL;DR: Results suggest that HSF1-mediated suppression of proinflammatory cytokines in the cochlea by GGA administration could be an important means of inner ear protection.
Journal ArticleDOI
Regulatory landscape of AGE-RAGE-oxidative stress axis and its modulation by PPARγ activation in high fructose diet-induced metabolic syndrome.
Luca Cannizzaro,Luca Cannizzaro,Giuseppe Rossoni,Federica Savi,Alessandra Altomare,Cristina Marinello,Thammakorn Saethang,Marina Carini,D. Michael Payne,Trairak Pisitkun,Giancarlo Aldini,Asada Leelahavanichkul +11 more
TL;DR: The data demonstrate the systems-level regulatory landscape of HFD-induced metabolic syndrome involving multiple molecular parameters, including HNE, AGEs and their receptor RAGE, and attenuation of metabolic syndrome by PPARγ modulation was significantly counteracted/prevented.
Journal ArticleDOI
Pioglitazone Represents an Effective Therapeutic Target in Preventing Oxidative/Inflammatory Cochlear Damage Induced by Noise Exposure
Fabiola Paciello,Anna Rita Fetoni,Rolando Rolesi,Matthew B. Wright,Claudio Grassi,Diana Troiani,Gaetano Paludetti +6 more
TL;DR: Investigation of the protective capacity of pioglitazone in a model of noise-induced hearing loss in Wistar rats and the molecular mechanisms underlying this protective effects found it was able to protect auditory function at the mid-high frequencies and to limit cell death in the cochlear basal/middle turn, damaged by noise exposure.
Journal ArticleDOI
Curcumin promotes oligodendrocyte differentiation and their protection against TNF-α through the activation of the nuclear receptor PPAR-γ.
TL;DR: In this article, the effects of curcumin on oligodendrocyte progenitor (OP) differentiation, particularly in inflammatory conditions, were investigated, and it was shown that the compound can promote the differentiation of OPs and counteract the maturation arrest induced by TNF-α by a mechanism involving PPAR-γ (peroxisome proliferator activated receptor).