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Open AccessJournal ArticleDOI

Non-enzymatic oxidized metabolite of DHA, 4(RS)-4-F4t-neuroprostane protects the heart against reperfusion injury

Jérôme Roy, +13 more
- 01 Jan 2017 - 
- Vol. 102, pp 229-239
TLDR
In conclusion, 4‐F4t‐NeuroP derived from DHA was able to protect I/R cardiac injuries by regulating the mitochondrial homeostasis and showed a strong anti‐apoptotic property involving the normalization of calciumHomeostasis by the stabilization of ryanodine receptor complex and to a decrease of mPTP opening leading to the reduction of pro‐APoptotic factors.
About: 
This article is published in Free Radical Biology and Medicine.The article was published on 2017-01-01 and is currently open access. It has received 39 citations till now. The article focuses on the topics: Mitochondrial permeability transition pore & Mitochondrial ROS.

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Citations
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Journal ArticleDOI

Physiological role of reactive oxygen species as promoters of natural defenses.

Jérôme Roy, +5 more
- 07 Jun 2017 - 
TL;DR: A new conception is unlocked about the involvement of cellular oxidants in the maintenance of redox homeostasis in redox regulation of normal physiological functions, and an explanation for its essential role in numerous pathophysiological states is noted.
Journal ArticleDOI

Isoprostanes, neuroprostanes and phytoprostanes : An overview of 25 years of research in chemistry and biology

Jean-Marie Galano, +7 more
- 01 Oct 2017 - 
TL;DR: This review explores in detail the isoprostanoid chemistry and biology that has been achieved in the past three decades.
Journal ArticleDOI

Role of Oxidative Stress in Reperfusion following Myocardial Ischemia and Its Treatments.

Mi Xiang, +13 more
- 18 May 2021 - 
TL;DR: In this paper, the pathological mechanisms of oxidative stress involved in reperfusion injury and the interventions for different pathways and targets, so as to form systematic treatments for oxidative stress-induced myocardial re-construction injury and make up for the lack of monotherapy.
Journal ArticleDOI

Human health benefits of very-long-chain polyunsaturated fatty acids from microalgae

Josselin Lupette, +1 more
- 07 May 2020 - 
TL;DR: This mini-review provides an inventory of knowledge on the synthesis of VLC-PUFAs in microalgae and on the diversity of signaling molecules (prostanoids, leukotrienes, SPMs, EFOX, isoprostanoids) that arise in humans from V LC- PUFAs.
Journal ArticleDOI

Profiling of Omega-Polyunsaturated Fatty Acids and Their Oxidized Products in Salmon after Different Cooking Methods

Kin Sum Leung, +3 more
- 24 Jul 2018 - 
TL;DR: Insight is provided into the application of heat and its effect on PUFAs and the release of its oxidized products in salmon as pan-frying and baking increased bioactive oxidized n-3 PUFA products, in particular F-4t-neuroprostanes derived from DHA.
References
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Journal ArticleDOI

Mitochondria and apoptosis

Douglas R. Green, +1 more
- 28 Aug 1998 - 
TL;DR: A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins.
Journal ArticleDOI

Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (dart)

Michael Leslie Burr, +7 more
- 30 Sep 1989 - 
TL;DR: A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.
Journal ArticleDOI

Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis

Jørn Dyerberg, +4 more
- 15 Jul 1978 - 
TL;DR: Unlike arachidonic acid, eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.X.A.P.), probably because of the formation of thromboxane A3 (T.G.I3) which does not have platelet aggregating properties.
Journal ArticleDOI

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria.

Sergey S Korshunov, +2 more
- 13 Oct 1997 - 
TL;DR: Inhibition of H2O2 formation by uncoupler, malonate and ADP+Pi is shown to be proportional to the ΔΨ decrease by these compounds, which is in line with the concept that a high proton motive force in state 4 is potentially dangerous for the cell due to an increase in the probability of superoxide formation.
Journal ArticleDOI

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

Takashi Nakagawa, +8 more
- 31 Mar 2005 - 
TL;DR: The results indicate that the CypD-dependent mPT regulates some forms of necrotic death, but not apoptotic death, as indicated by resistance to ischaemia/reperfusion-induced cardiac injury.
Related Papers (5)

Isoprostanes, neuroprostanes and phytoprostanes : An overview of 25 years of research in chemistry and biology

Jean-Marie Galano, +7 more
- 01 Oct 2017 - 

Oxygenated metabolites of n-3 polyunsaturated fatty acids as potential oxidative stress biomarkers: total synthesis of 8-F3t-IsoP, 10-F4t-NeuroP and [D4]-10-F4t-NeuroP

Alexandre Guy, +7 more
- 19 May 2014 - 

The handy use of Brown's P2-Ni catalyst for a skipped diyne deuteration: application to the synthesis of a [D4]-labeled F4t-neuroprostane.

Camille Oger, +6 more
- 17 Dec 2010 - 

The isoprostanes--25 years later.

Ginger L. Milne, +2 more
- 01 Apr 2015 - 

A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.

Jason D. Morrow, +5 more
- 01 Dec 1990 - 
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