Nosocomial infections among patients with COVID-19, SARS and MERS: A rapid review and meta-analysis
Qi Zhou,Yelei Gao,Xingmei Wang,Rui Liu,Peipei Du,Xiaoqing Wang,Xianzhuo Zhang,Shuya Lu,Shuya Lu,Shuya Lu,Zijun Wang,Qianling Shi,Weiguo Li,Yanfang Ma,Xufei Luo,Toshio Fukuoka,Hyeong Sik Ahn,Hyeong Sik Ahn,Myeong Soo Lee,Enmei Liu,Yaolong Chen,Zhengxiu Luo,Kehu Yang,Covid Evidence +23 more
TLDR
The proportion of nosocomial infection in patients with COVID-19 was 44% in the early outbreak, and nurses and doctors were the most affected among the infected medical staff.Abstract:
Background COVID-19, a disease caused by SARS-CoV-2 coronavirus, has now spread to most countries and regions of the world. As patients potentially infected by SARS-CoV-2 need to visit hospitals, the incidence of nosocomial infection can be expected to be high. Therefore, a comprehensive and objective understanding of nosocomial infection is needed to guide the prevention and control of the epidemic. Methods We searched major international and Chinese databases: Medicine, Web of Science, Embase, Cochrane, CBM (China Biology Medicine disc), CNKI (China National Knowledge Infrastructure) and Wanfang database for case series or case reports on nosocomial infections of COVID-19, SARS (severe acute respiratory syndromes) and MERS (Middle East respiratory syndrome) from their inception to March 31st, 2020. We conducted a meta-analysis of the proportion of nosocomial infection patients in the diagnosed patients, occupational distribution of nosocomial infection medical staff. Results We included 40 studies. Among the confirmed patients, the proportions of nosocomial infections with early outbreaks of COVID-19, SARS, and MERS were 44.0%, 36.0%, and 56.0%, respectively. Of the confirmed patients, the medical staff and other hospital-acquired infections accounted for 33.0% and 2.0% of COVID-19 cases, 37.0% and 24.0% of SARS cases, and 19.0% and 36.0% of MERS cases, respectively. Nurses and doctors were the most affected among the infected medical staff. The mean numbers of secondary cases caused by one index patient were 29.3 and 6.3 for SARS and MERS, respectively. Conclusions The proportion of nosocomial infection in patients with COVID-19 was 44% in the early outbreak. Patients attending hospitals should take personal protection. Medical staff should be awareness of the disease to protect themselves and the patients.read more
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A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Jasper Fuk-Woo Chan,Shuofeng Yuan,Kin-Hang Kok,Kelvin K. W. To,Kelvin K. W. To,Hin Chu,Jin Yang,Fanfan Xing,Jieling Liu,Cyril C. Y. Yip,Rosana W.S. Poon,Hoi Wah Tsoi,Simon Kam Fai Lo,Kwok-Hung Chan,Vincent Kwok-Man Poon,Wan Mui Chan,Jonathan Daniel Ip,Jian Piao Cai,Vincent C.C. Cheng,Honglin Chen,Honglin Chen,Christopher K.M. Hui,Kwok-Yung Yuen +22 more
TL;DR: The findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions.
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Incidence of Nosocomial COVID-19 in Patients Hospitalized at a Large US Academic Medical Center.
Chanu Rhee,Meghan A Baker,Vineeta Vaidya,Robert Tucker,Andrew Resnick,Charles A. Morris,Michael Klompas,Cdc Prevention Epicenters Program +7 more
TL;DR: This cohort study evaluates the incidence of nosocomial coronavirus disease 2019 (COVID-19) among patients admitted to a US medical center in the context of a comprehensive and progressive infection control program.
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Evolution and effects of COVID-19 outbreaks in care homes: a population analysis in 189 care homes in one geographical region of the UK
Jennifer K Burton,Gwen Bayne,C. J. Evans,Frederike Garbe,D.R. Gorman,Naomi Honhold,Duncan McCormick,Richard Othieno,J Stevenson,Stefanie Swietlik,Kate Templeton,Mette Tranter,L.J. Willocks,Bruce Guthrie +13 more
TL;DR: The effect of COVID-19 on care homes has been substantial but concentrated in care homes with known outbreaks, and a key implication from the findings is that, if community incidence of CO VID-19 increases again, many care home residents will be susceptible.
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Nosocomial COVID-19 infection: examining the risk of mortality. The COPE-Nosocomial Study (COVID in Older PEople).
Ben Carter,Jemima T. Collins,Fenella Barlow-Pay,Frances Rickard,E Bruce,Alessia Verduri,Terence J. Quinn,Emma Mitchell,Angeline Price,A. Vilches-Moraga,Michael Stechman,Roxanna Short,Alice Einarsson,Philip Braude,Susan Moug,Phyo K. Myint,Jonathan Hewitt,Lyndsay Pearce,Kathryn McCarthy +18 more
TL;DR: Patients with NC had a reduced risk of mortality compared to CAC infection, however, caution should be taken when interpreting this finding.
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Hospital-Acquired SARS-CoV-2 Infection: Lessons for Public Health.
TL;DR: This Viewpoint reviews the rare incidence of nosocomial SARS-CoV-2 infection and discusses ways it can be minimized, including use of surgical masks, proper ventilation, physical distancing, eye protection, regular testing, and the availability of sick leave for health care workers.
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