Journal ArticleDOI
Novel cationic pH-responsive poly(N,N-dimethylaminoethyl methacrylate) microcapsules prepared by a microfluidic technique.
Jie Wei,Xiao-Jie Ju,Rui Xie,Chuan-Lin Mou,Xi Lin,Liang-Yin Chu +5 more
- Vol. 357, Iss: 1, pp 101-108
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TLDR
The fabrication methodology and results in this study provide valuable guidance for preparation of core-shell microcapsules via free radical polymerization based on synergistic effects of interfacial initiation and initiation in a confined space.Abstract:
Novel monodisperse cationic pH-responsive microcapsules are successfully prepared using oil-in-water-in-oil double emulsions as templates by a microfluidic technique in this study. With the use of a double photo-initiation system and the adjustment of pH value of the monomer solution, cross-linked poly( N , N -dimethylaminoethyl methacrylate) (PDM) microcapsules with good sphericity and monodispersity can be effectively fabricated. The obtained microcapsule membranes swell at low pH due to the protonation of N(CH 3 ) 2 groups in the cross-linked PDM networks. The effects of various preparation parameters, such as pH of the aqueous monomer fluid, concentration of cross-linker, concentration of monomer N , N -dimethylaminoethyl methacrylate (DM) and addition of copolymeric monomer acrylamide (AAm), on the pH-responsive swelling characteristics of PDM microcapsules are systematically studied. The results show that, when the PDM microcapsules are prepared at high pH and with low cross-linking density and low DM monomer concentration, they exhibit high pH-responsive swelling ratios. The addition of AAm in the preparation decreases the swelling ratios of PDM microcapsules. The external temperature has hardly any influence on the swelling ratios of PDM microcapsules when the external pH is less than 7.4. The prepared PDM microcapsules with both biocompatibility and cationic pH-responsive properties are of great potential as drug delivery carriers for tumor therapy. Moreover, the fabrication methodology and results in this study provide valuable guidance for preparation of core–shell microcapsules via free radical polymerization based on synergistic effects of interfacial initiation and initiation in a confined space.read more
Citations
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Journal ArticleDOI
Cationic polymers and their therapeutic potential
Sangram Keshari Samal,Mamoni Dash,Sandra Van Vlierberghe,David L. Kaplan,Emo Chiellini,Clemens van Blitterswijk,Lorenzo Moroni,Peter Dubruel +7 more
TL;DR: The most recent scientific advances in cationic polymers and their derivatives not only for gene delivery purposes but also for various alternative therapeutic applications are reviewed.
Journal ArticleDOI
Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery
TL;DR: This review presents an overview of the state-of-the-art multiphase flow microfluidics for the production of single emulsions or multiple emulsion droplets for drug delivery.
Journal ArticleDOI
Recent advances of controlled drug delivery using microfluidic platforms.
TL;DR: This article reviews recent advances of controlled drug delivery using microfluidic platforms which can be implanted in human bodies to control drug release in real time through an on‐demand feedback mechanism.
Journal ArticleDOI
Microfluidic production of multiple emulsions and functional microcapsules
TL;DR: The three main sections of this paper discuss distinct microfluidic techniques developed for the generation of multiple emulsions, four representative methods used for solid membrane formation, and various applications of functional microcapsules.
Journal ArticleDOI
Autonomic Shutdown of Lithium-Ion Batteries Using Thermoresponsive Microspheres
Marta Baginska,Benjamin J. Blaiszik,Ryan J. Merriman,Nancy R. Sottos,Jeffrey S. Moore,Scott R. White +5 more
TL;DR: In this article, thermally-induced shutdown of Li-ion batteries is demonstrated by incorporating thermoresponsive polymer microspheres (ca 4 µ m) onto battery anodes or separators.
References
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Journal Article
Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: A Review
TL;DR: Current knowledge of blood flow and perfusion-related parameters, which usually go hand in hand and in turn define the cellular metabolic microenvironment of human malignancies, are summarized for predicting the acute and/or long-term response of tumors to therapy.
Journal ArticleDOI
Thermo- and pH-responsive polymers in drug delivery.
TL;DR: The majority of examples, discussed in this paper, deal with pH-responsive drug delivery system, and Thermo-responsive polymer is also covered to a large extent, as well as double-responsive system.
Journal ArticleDOI
Controllable monodisperse multiple emulsions.
TL;DR: The structure of multiple emulsion systems is in this case defined as the number of bubbles contained in each size "level" of larger bubbles.
Journal ArticleDOI
Co-delivery of siRNA and paclitaxel into cancer cells by biodegradable cationic micelles based on PDMAEMA-PCL-PDMAEMA triblock copolymers.
TL;DR: Results demonstrated that cationic biodegradable micelles are highly promising for the combinatorial delivery of siRNA and lipophilic anti-cancer drugs.
Journal ArticleDOI
PH-responsive properties of hollow polyelectrolyte microcapsules templated on various cores
TL;DR: The structuring effect of tetrahydrofuran on the multilayers has been demonstrated and it is shown that increasing the molecular weight of the polymers or the number of layers causes also a rigidification of the structure and modifies the pH response.
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