Recent advances of controlled drug delivery using microfluidic platforms.
Reads0
Chats0
TLDR
This article reviews recent advances of controlled drug delivery using microfluidic platforms which can be implanted in human bodies to control drug release in real time through an on‐demand feedback mechanism.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2017-09-15 and is currently open access. It has received 231 citations till now. The article focuses on the topics: Drug delivery & Drug carrier.read more
Citations
More filters
Journal ArticleDOI
3D printed microneedles for insulin skin delivery
Cristiane Patricia Pissinato Pere,Sophia N. Economidou,Gurprit S. Lall,Clémentine Ziraud,Joshua S. Boateng,Bruce D. Alexander,Dimitrios A. Lamprou,Dennis Douroumis +7 more
TL;DR: 3D printing was proved an effective technology for the fabrication of biocompatible and scalable microneedle patches and maintained the native form of insulin, with xylitol presenting the best performance.
Journal ArticleDOI
Recent advances of microneedles for biomedical applications: drug delivery and beyond.
TL;DR: In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing (3DP).
Journal ArticleDOI
Fabrication and Applications of Microfluidic Devices: A Review.
Adelina-Gabriela Niculescu,Cristina Chircov,Alexandra Cătălina Bîrcă,Alexandru Mihai Grumezescu,Alexandru Mihai Grumezescu +4 more
TL;DR: In this article, the authors present microfluidic technology in terms of the available platform materials and fabrication techniques, also focusing on the biomedical applications of these remarkable devices, including nanoparticle preparation, drug encapsulation, delivery, and targeting, cell analysis, diagnosis, and cell culture.
Journal ArticleDOI
Microfluidic Sonication To Assemble Exosome Membrane-Coated Nanoparticles for Immune Evasion-Mediated Targeting
Chao Liu,Chao Liu,Wei Zhang,Wei Zhang,Yike Li,Yike Li,Jianqiao Chang,Fei Tian,Fei Tian,Fanghao Zhao,Yao Ma,Yao Ma,Jiashu Sun,Jiashu Sun +13 more
TL;DR: Tumor cell-derived EM-coated PLGA NPs consisting of both endosomal and plasma membrane proteins show superior homotypic targeting as compared to CCM-PL GA NPs of similar sizes and core-shell structures in both in vitro and in vivo models.
Journal ArticleDOI
3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery
Sophia N. Economidou,Cristiane Patricia Pissinato Pere,Andrew Reid,Md. Jasim Uddin,James F. C. Windmill,Dimitrios A. Lamprou,Dennis Douroumis +6 more
TL;DR: In vivo animal trials revealed fast insulin action with excellent hypoglycaemia control and lower glucose levels achieved within 60 min, combined with steady state plasma glucose over 4 h compared to subcutaneous injections.
References
More filters
Journal ArticleDOI
Principles of nanoparticle design for overcoming biological barriers to drug delivery
TL;DR: By successively addressing each of the biological barriers that a particle encounters upon intravenous administration, innovative design features can be rationally incorporated that will create a new generation of nanotherapeutics, realizing a paradigmatic shift in nanoparticle-based drug delivery.
Journal ArticleDOI
Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal ArticleDOI
Transdermal drug delivery
Mark R. Prausnitz,Robert Langer +1 more
TL;DR: Third-generation delivery systems target their effects to skin's barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound for delivery of macromolecules and vaccines.
Journal ArticleDOI
Chitosan chemistry and pharmaceutical perspectives.
TL;DR: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. S. Nagar, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of medicine, Jerusalem 91120, Israel.
Journal ArticleDOI
Cancer Nanotechnology: The impact of passive and active targeting in the era of modern cancer biology
TL;DR: The fundamental concepts of enhanced permeability and retention effect (EPR) are revisited and the mechanisms proposed to enhance preferential "retention" in the tumor, whether using active targeting of nanoparticles, binding of drugs to their tumoral targets or the presence of tumor associated macrophages are explored.