Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T.
Craig K. Jones,Alan J. Huang,Jiadi Xu,Jiadi Xu,Richard A.E. Edden,Richard A.E. Edden,Michael Schär,Jun Hua,Jun Hua,Nikita Oskolkov,Nikita Oskolkov,Domenico Zacà,Jinyuan Zhou,Jinyuan Zhou,Michael T. McMahon,Michael T. McMahon,Jay J. Pillai,Peter C.M. van Zijl,Peter C.M. van Zijl +18 more
TLDR
First data on a tumor patient show reduction in both relayed NOE and CEST amid proton signals leading to an increase in magnetization transfer ratio asymmetry, providing insight into previously reported amide proton transfer (APT) effects in tumors.About:
This article is published in NeuroImage.The article was published on 2013-08-15 and is currently open access. It has received 264 citations till now. The article focuses on the topics: Magnetization transfer.read more
Citations
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Journal ArticleDOI
Pros and cons of ultra-high-field MRI/MRS for human application.
Mark E. Ladd,Peter Bachert,Peter Bachert,Martin Meyerspeer,Ewald Moser,Armin M. Nagel,Armin M. Nagel,David G. Norris,David G. Norris,Sebastian Schmitter,Sebastian Schmitter,Oliver Speck,Sina Straub,Moritz Zaiss +13 more
TL;DR: An overview of some of the latest methodological developments in human ultra-high field MRI/MRS as well as associated clinical and scientific applications is presented, with emphasis on techniques that particularly benefit from the changing physical characteristics at high magnetic fields.
Journal ArticleDOI
Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods.
Moritz Zaiss,Peter Bachert +1 more
TL;DR: This review considers analytical solutions of the Bloch–McConnell (BM) equation system which enable deep insight and theoretical description of CEST and the equivalent off-resonant spinlock (SL) experiments and derive and discuss proposed theoretical treatments in detail to understand the influence of saturation parameters on the acquired Z-spectrum and how the different effects interfere and can be isolated in MR Z-Spectroscopy.
Journal ArticleDOI
Inverse Z-spectrum analysis for spillover-, MT-, and T1 -corrected steady-state pulsed CEST-MRI--application to pH-weighted MRI of acute stroke.
Moritz Zaiss,Junzhong Xu,Steffen Goerke,Imad Saeed Khan,Robert J. Singer,John C. Gore,Daniel F. Gochberg,Peter Bachert +7 more
TL;DR: A spillover correction is of special interest for clinical static field strengths and protons resonating near the water peak, as it forms the motivation for simple metrics that correct the CEST signal.
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Magnetization Transfer Contrast and Chemical Exchange Saturation Transfer MRI. Features and analysis of the field-dependent saturation spectrum
Peter C.M. van Zijl,Peter C.M. van Zijl,Wilfred W. Lam,Jiadi Xu,Linda Knutsson,Greg J. Stanisz,Greg J. Stanisz,Greg J. Stanisz +7 more
TL;DR: Basics of nuclear Overhauser enhancement (NOE) and chemical exchange saturation transfer (CEST) and comprehensive description of the features of the endogenous saturation spectrum (Z‐spectrum) in MRI are described.
Journal ArticleDOI
Clinical applications of chemical exchange saturation transfer (CEST) MRI
TL;DR: These CEST MRI tools show promise for contributing to assessments of cerebral ischemia, neurological disorders, lymphedema, osteoarthritis, muscle physiology, and solid tumors.
References
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Estimation of metabolite concentrations from localized in vivo proton NMR spectra
TL;DR: The LCModel method analyzes an in vivo spectrum as a Linear Combination of Model spectra of metabolite solutions in vitro by using complete model spectra, rather than just individual resonances, to ensure maximum information and uniqueness are incorporated into the analysis.
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Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo
TL;DR: The extent of exchange between 1Hf and 1Hr as well as the topological correlation ofthe exchange with relaxation weighted images suggests that this pathway is a major determinant of the observed relaxation properties of water 1H in vivo.
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A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST).
TL;DR: Data demonstrate that a CEST-based exogenous contrast agent for MRI is feasible and the best chemical exchange site found was the 5.33-ppm indole ring -NH site of 5-hydroxytryptophan.
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Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI.
Jinyuan Zhou,Jinyuan Zhou,Jean Francois Payen,Jean Francois Payen,David A. Wilson,Richard J. Traystman,Peter C.M. van Zijl,Peter C.M. van Zijl +7 more
TL;DR: P pH effects were noninvasively imaged in ischemic rat brain to show the potential of amide proton transfer (APT) contrast for detecting acute stroke, and opens the possibility of using intrinsic pH contrast, as well as protein- and/or peptide-content contrast, in clinical imaging.
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In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time.
TL;DR: Using optimized, asymmetric radiofrequency (RF) pulses for slice selection, the authors demonstrate that stimulated echo acquisition mode (STEAM) localization with ultra‐short echo time (1 ms) is possible, resulting in highly resolved in vivo 1H nuclear magnetic resonance spectra.