Journal ArticleDOI
Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring.
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TLDR
Data indicate that a novel, lengthwise (‘spring-like’) conformational change in a dynamin helix may participate in vesicle fission during GTP hydrolysis by dynamin.Abstract:
Nucleotide-dependent conformational changes in dynamin: evidence for
a mechanochemical molecular springread more
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Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
Journal ArticleDOI
Mechanisms of Endocytosis
TL;DR: What is known about mammalian endocytic mechanisms is reviewed, with focus on the cellular proteins that control these events, and the functional relevance of distinctendocytic pathways is discussed.
Journal ArticleDOI
Membrane curvature and mechanisms of dynamic cell membrane remodelling
TL;DR: Membrane curvature is no longer seen as a passive consequence of cellular activity but an active means to create membrane domains and to organize centres for membrane trafficking.
Journal ArticleDOI
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
TL;DR: Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a clathrin coat and is fundamental to neurotransmission, signal transduction and the regulation of many plasma membrane activities and is thus essential to higher eukaryotic life.
Journal ArticleDOI
Dynasore, a Cell-Permeable Inhibitor of Dynamin
Eric Macia,Marcelo Ehrlich,Ramiro Massol,Emmanuel Boucrot,Christian Brunner,Tomas Kirchhausen +5 more
TL;DR: Dynamin acts at two steps during clathrin coat formation; GTP hydrolysis is probably needed at both steps; Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition.
References
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Journal ArticleDOI
On the Nature of Allosteric Transitions: A Plausible Model
TL;DR: "It is certain that all bodies whatsoever, though they have no sense, yet they have perception, and whether the body be alterant or alterec, evermore a perception precedeth operation; for else all bodies would be like one to another."
Patent
Three dimensional structure memory
TL;DR: The 3Dimensional Structure (3DS) Memory (100) as mentioned in this paper is a three-dimensional structure (3D) memory that allows physical separation of the memory circuits and the control logic circuit onto different layers such that each layer may be separately optimized.
Journal ArticleDOI
Elastic deformation and failure of lipid bilayer membranes containing cholesterol.
David Needham,R. S. Nunn +1 more
TL;DR: The results indicated that the presence of cholesterol is the single most influential factor in increasing bilayer cohesion, but only for lipids where both chains are saturated, or mono- or diunsaturated, and multiple unsaturation in both lipid chains inhibits the condensing effect of cholesterol in bilayers.
Journal ArticleDOI
CLATHRIN-COATED VESICLE FORMATION AND PROTEIN SORTING: An Integrated Process
TL;DR: The functional interplay between the coated vesicle machinery and its cargo could ensure sorting fidelity and packaging efficiency and might enable modulation of vesicular trafficking in response to demand.
Journal ArticleDOI
Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals
TL;DR: These findings demonstrate that dynamin and clathrin act at different sites in the formation of endocytic vesicles and suggest that stabilization of the GTP-bound conformation of dynamin leads to tubule formation by progressive elongation of the vesicle stalk.