Journal ArticleDOI
Nutrigenomics and nutrigenetics.
Jose M. Ordovas,Vincent Mooser +1 more
TLDR
It is anticipated that in the future the authors will be able to harness the information contained in their genomes to achieve successful aging using behavioral changes, with nutrition being the cornerstone of this endeavor.Abstract:
Purpose of reviewNutritional genomics has tremendous potential to change the future of dietary guidelines and personal recommendations. Nutritional genomics covers nutrigenomics, which explores the effects of nutrients on the genome, proteome and metabolome, and nutrigenetics, the major goal of whicread more
Citations
More filters
Journal ArticleDOI
Biomarkers in nutritional epidemiology: applications, needs and new horizons
TL;DR: This review emphasizes the need to identify new dietary biomarkers and highlights the emerging field of nutritional metabonomics as an analytical method to assess metabolic profiles as measures of dietary exposures and indicators of dietary patterns, dietary changes or effectiveness of dietary interventions.
Journal ArticleDOI
Nutrigenomics and nutrigenetics: the emerging faces of nutrition
TL;DR: The current review aims to position nutrigenomics and Nutrigenetics as the emerging faces of nutrition that, when considered with more classical approaches, will provide the necessary stepping stones to achieve the ambitious goal of optimizing an individual's health via nutritional intervention.
Journal ArticleDOI
A Critical Appraisal of the Scientific Basis of Commercial Genomic Profiles Used to Assess Health Risks and Personalize Health Interventions
A. Cecile J.W. Janssens,Marta Gwinn,Linda A. Bradley,Ben A. Oostra,Cornelia M. van Duijn,Muin J. Khoury +5 more
TL;DR: There is insufficient scientific evidence to conclude that genomic profiles are useful in measuring genetic risk for common diseases or in developing personalized diet and lifestyle recommendations for disease prevention.
Journal ArticleDOI
OMICS-driven biomarker discovery in nutrition and health.
TL;DR: This paper reviews the state-of-the-art of the three Omics platforms, discusses their implication in nutrigenomics and elaborates on applications in nutrition and health such as digestive health, allergy, diabetes and obesity, nutritional intervention and nutrient bioavailability.
Journal ArticleDOI
Nutrigenomics: from molecular nutrition to prevention of disease.
Lydia A. Afman,Michael Müller +1 more
TL;DR: Nutrigenomics will promote an increased understanding of how nutrition influences metabolic pathways and homeostatic control, how this regulation is disturbed in the early phases of diet-related disease, and the extent to which individual sensitizing genotypes contribute to such diseases.
References
More filters
Journal ArticleDOI
Global and societal implications of the diabetes epidemic
TL;DR: The prevention of diabetes and control of its micro- and macrovascular complications will require an integrated, international approach if the authors are to see significant reduction in the huge premature morbidity and mortality it causes.
Journal ArticleDOI
A vision for the future of genomics research
TL;DR: The Human Genome Project (HGP) as mentioned in this paper was the first attempt to obtain a high-quality, comprehensive sequence of the human genome, in this fiftieth anniversary year of the discovery of the double-helical structure of DNA.
Journal ArticleDOI
Nutrigenomics: goals and strategies
Michael Müller,Sander Kersten +1 more
TL;DR: Applied wisely, nutrigenomics will allow effective dietary-intervention strategies to recover normal homeostasis and to prevent diet-related diseases.
Journal ArticleDOI
Evidence for Gene-Nutrient Interaction at the PPARγ Locus
Jian'an Luan,Paul O. Browne,Anne-Helen Harding,David Halsall,Stephen O'Rahilly,V. Krishna K. Chatterjee,Nicholas J. Wareham +6 more
TL;DR: The data suggest that when the dietary P:S ratio is low, the BMI in Ala carriers is greater than that in Pro homozygotes, but when the nutritional ratio is high, the opposite is seen.
Journal ArticleDOI
Interaction between a peroxisome proliferator-activated receptor γ gene polymorphism and dietary fat intake in relation to body mass
Asli Memisoglu,Frank B. Hu,Susan E. Hankinson,JoAnn E. Manson,Immaculata De Vivo,Walter C. Willett,David J. Hunter +6 more
TL;DR: Data suggest that PPAR gamma genotype is an important factor in physiological responses to dietary fat in humans and modifies the association between dietary fat and adiposity and plasma lipids.
Related Papers (5)
Nutrigenomics and nutrigenetics: the emerging faces of nutrition
Nutritional genomics: the next frontier in the postgenomic era
Jim Kaput,Raymond L. Rodriguez +1 more