Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease.
Cielo García-Montero,Oscar Fraile-Martínez,Ana M Gómez-Lahoz,Leonel Pekarek,Alejandro J. Castellanos,Fernando Noguerales-Fraguas,Santiago Coca,Santiago Coca,Luis G. Guijarro,Natalio García-Honduvilla,Natalio García-Honduvilla,Ángel Asúnsolo,Ángel Asúnsolo,Lara Sanchez-Trujillo,Lara Sanchez-Trujillo,Guillermo Lahera,Guillermo Lahera,Julia Buján,Julia Buján,Jorge Monserrat,Jorge Monserrat,Melchor Alvarez-Mon,Miguel Angel Alvarez-Mon,Miguel A Ortega +23 more
Reads0
Chats0
TLDR
In this article, the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.Abstract:
The most prevalent diseases of our time, non-communicable diseases (NCDs) (including obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising worldwide. All of them share the condition of an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have in common malnutrition related to physiopathology. In this context, diet is the greatest modulator of immune system–microbiota crosstalk, and much interest, and new challenges, are arising in the area of precision nutrition as a way towards treatment and prevention. It is a fact that the westernized diet (WD) is partly responsible for the increased prevalence of NCDs, negatively affecting both gut microbiota and the immune system. Conversely, other nutritional approaches, such as Mediterranean diet (MD), positively influence immune system and gut microbiota, and is proposed not only as a potential tool in the clinical management of different disease conditions, but also for prevention and health promotion globally. Thus, the purpose of this review is to determine the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.read more
Citations
More filters
Journal ArticleDOI
Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management
Miguel A Ortega,Oscar Fraile-Martínez,Oscar Fraile-Martínez,Cielo García-Montero,Cielo García-Montero,Miguel Angel Alvarez-Mon,Miguel Angel Alvarez-Mon,Chen Chaowen,Fernando Ruiz-Grande,Leonel Pekarek,Leonel Pekarek,Jorge Monserrat,Jorge Monserrat,Ángel Asúnsolo,Natalio García-Honduvilla,Natalio García-Honduvilla,Melchor Alvarez-Mon,Melchor Alvarez-Mon,Julia Buján,Julia Buján +19 more
TL;DR: In this paper, the authors present a review of the current knowledge of chronic venous disease, including its epidemiology, etiology, and risk factors, emphasizing the pathophysiology and medical care of these patients, including clinical manifestations, diagnosis, and treatments.
Journal ArticleDOI
Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights.
Bernard Srour,Melissa C. Kordahi,Erica Bonazzi,Mélanie Deschasaux-Tanguy,Mathilde Touvier,Benoit Chassaing +5 more
TL;DR: In this article , an overview of the current data that highlight an association between ultra-processed food consumption and various chronic diseases, with a focus on epidemiological evidence and mechanistic insights involving the intestinal microbiota.
Journal ArticleDOI
Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications
Miguel A Ortega,Miguel Angel Alvarez-Mon,C. García-Montero,Oscar Fraile-Martínez,Luis G. Guijarro,Guillermo Lahera,Jorge Monserrat,Paula Valls,Fernando Mora,Roberto Rodriguez-Jimenez,Javier Quintero,Melchor Alvarez-Mon +11 more
TL;DR: The main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology.
Journal ArticleDOI
The Mediterranean Diet: An Update of the Clinical Trials
TL;DR: An update of the clinical trials registered on the database clinicaltrials.gov evaluating the effects of the MedDiet on health and specific diseases and an increased number of clinical trials in the last decade were revealed.
Journal ArticleDOI
Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress.
TL;DR: In this paper, the effects of the probiotic Bacillus subtilis on skeletal health of broiler chickens exposed to heat stress was investigated. But the authors focused on the effects on the health and welfare of the animals.
References
More filters
Journal ArticleDOI
The gut microbiota: A treasure for human health.
TL;DR: It appears that the relationship between the gut microbiota and disease is bidirectional, instead of causal or consequential, and personalized nutritional and therapeutic strategies targeting the Gut microbiota may create a new era in the human health.
Journal ArticleDOI
Intestinal M cells
TL;DR: This work discusses recent advances in the understanding of the molecular mechanisms of M-cell differentiation and functions and describes how M cells are highly specialized to take up intestinal microbial antigens and deliver them to GALT for efficient mucosal as well as systemic immune responses.
Journal ArticleDOI
Impacts of microbiome metabolites on immune regulation and autoimmunity.
Stefanie Haase,Aiden Haghikia,Nicola Wilck,Dominik N. Müller,Dominik N. Müller,Ralf A. Linker +5 more
TL;DR: New aspects of host–microbiota interaction and the immune system are discussed with a special focus on MS as a prototype T‐cell‐mediated autoimmune disease of the CNS.
OtherDOI
Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis.
TL;DR: As SCFA are obligatory for optimal colonic health, the transporters responsible for the entry and transcellular transfer of these bacterial products in colonic epithelium are critical determinants of colonic function under physiological conditions and in disease states.
Journal ArticleDOI
The food matrix: implications in processing, nutrition and health
TL;DR: The effect of the food matrix (FM-effect) is discussed in reference to food processing, oral processing and flavor perception, satiation and satiety, and digestion in the gastrointestinal tract, and a classification for the major types of matrices found in foods is proposed.
Related Papers (5)
Diet-microbiota interactions and their implications for healthy living.
Ian B. Jeffery,Paul W. O'Toole +1 more