Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease.
Cielo García-Montero,Oscar Fraile-Martínez,Ana M Gómez-Lahoz,Leonel Pekarek,Alejandro J. Castellanos,Fernando Noguerales-Fraguas,Santiago Coca,Santiago Coca,Luis G. Guijarro,Natalio García-Honduvilla,Natalio García-Honduvilla,Ángel Asúnsolo,Ángel Asúnsolo,Lara Sanchez-Trujillo,Lara Sanchez-Trujillo,Guillermo Lahera,Guillermo Lahera,Julia Buján,Julia Buján,Jorge Monserrat,Jorge Monserrat,Melchor Alvarez-Mon,Miguel Angel Alvarez-Mon,Miguel A Ortega +23 more
Reads0
Chats0
TLDR
In this article, the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.Abstract:
The most prevalent diseases of our time, non-communicable diseases (NCDs) (including obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising worldwide. All of them share the condition of an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have in common malnutrition related to physiopathology. In this context, diet is the greatest modulator of immune system–microbiota crosstalk, and much interest, and new challenges, are arising in the area of precision nutrition as a way towards treatment and prevention. It is a fact that the westernized diet (WD) is partly responsible for the increased prevalence of NCDs, negatively affecting both gut microbiota and the immune system. Conversely, other nutritional approaches, such as Mediterranean diet (MD), positively influence immune system and gut microbiota, and is proposed not only as a potential tool in the clinical management of different disease conditions, but also for prevention and health promotion globally. Thus, the purpose of this review is to determine the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.read more
Citations
More filters
Journal ArticleDOI
Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management
Miguel A Ortega,Oscar Fraile-Martínez,Oscar Fraile-Martínez,Cielo García-Montero,Cielo García-Montero,Miguel Angel Alvarez-Mon,Miguel Angel Alvarez-Mon,Chen Chaowen,Fernando Ruiz-Grande,Leonel Pekarek,Leonel Pekarek,Jorge Monserrat,Jorge Monserrat,Ángel Asúnsolo,Natalio García-Honduvilla,Natalio García-Honduvilla,Melchor Alvarez-Mon,Melchor Alvarez-Mon,Julia Buján,Julia Buján +19 more
TL;DR: In this paper, the authors present a review of the current knowledge of chronic venous disease, including its epidemiology, etiology, and risk factors, emphasizing the pathophysiology and medical care of these patients, including clinical manifestations, diagnosis, and treatments.
Journal ArticleDOI
Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights.
Bernard Srour,Melissa C. Kordahi,Erica Bonazzi,Mélanie Deschasaux-Tanguy,Mathilde Touvier,Benoit Chassaing +5 more
TL;DR: In this article , an overview of the current data that highlight an association between ultra-processed food consumption and various chronic diseases, with a focus on epidemiological evidence and mechanistic insights involving the intestinal microbiota.
Journal ArticleDOI
Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications
Miguel A Ortega,Miguel Angel Alvarez-Mon,C. García-Montero,Oscar Fraile-Martínez,Luis G. Guijarro,Guillermo Lahera,Jorge Monserrat,Paula Valls,Fernando Mora,Roberto Rodriguez-Jimenez,Javier Quintero,Melchor Alvarez-Mon +11 more
TL;DR: The main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology.
Journal ArticleDOI
The Mediterranean Diet: An Update of the Clinical Trials
TL;DR: An update of the clinical trials registered on the database clinicaltrials.gov evaluating the effects of the MedDiet on health and specific diseases and an increased number of clinical trials in the last decade were revealed.
Journal ArticleDOI
Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress.
TL;DR: In this paper, the effects of the probiotic Bacillus subtilis on skeletal health of broiler chickens exposed to heat stress was investigated. But the authors focused on the effects on the health and welfare of the animals.
References
More filters
Book ChapterDOI
Metalloimmunology: The metal ion-controlled immunity.
TL;DR: This review summarizes recent advances in the understanding of metal-controlled immunity by focusing on the mechanisms of innate immune stimulation and T cell activation by the essential metal ions like calcium (Ca2+), zinc (Zn), manganese (Mn), nickel (Ni), copper (Cu) and cobalt (Co), followed by a few unessential metals.
Journal ArticleDOI
WASH—World Action on Salt and Health
TL;DR: The average salt intake in most countries around the world is E9-12 g/day, with many Asian countries having mean intakes over 12g/day as mentioned in this paper, which is the highest in the world.
Journal ArticleDOI
Diverse Intestinal Bacteria Contain Putative Zwitterionic Capsular Polysaccharides with Anti-inflammatory Properties.
C. Preston Neff,Matthew E. Rhodes,Kathleen L. Arnolds,Colm B. Collins,Jody Donnelly,Nichole M. Nusbacher,Paul Jedlicka,Jennifer M. Schneider,Martin D. McCarter,Michael Shaffer,Sarkis K. Mazmanian,Brent E. Palmer,Catherine A. Lozupone +12 more
TL;DR: A genomic screen for bacteria encoding ZPS molecules is presented and diverse host-associated bacteria, including commensals and pathogens with known anti-inflammatory properties, with the capacity to produce ZPSs are identified.
Book ChapterDOI
Regulation of Interleukin-10 Expression
Sascha Rutz,Wenjun Ouyang +1 more
TL;DR: It is examined in more detail how various signals in CD4+ T cells converge on common transcriptional circuits, which fine-tune IL-10 expression in a context-dependent manner.
Journal ArticleDOI
Pulmonary Th17 Antifungal Immunity Is Regulated by the Gut Microbiome
Jeremy P. McAleer,Nikki L. H. Nguyen,Kong Chen,Pawan Kumar,David M. Ricks,Matthew Binnie,Rachel A. Armentrout,Derek Pociask,Aaron Hein,Amy Yu,Amit Vikram,Kyle Bibby,Yoshinori Umesaki,Amariliz Rivera,Dean Sheppard,Wenjun Ouyang,Lora V. Hooper,Jay K. Kolls +17 more
TL;DR: It is shown that gut microbiota can regulate CD4 T cell polarization during pulmonary fungal infections and serum-transfer experiments revealed that IL-1R ligands increase the accumulation of lung Th17 cells, suggesting that intestinal microbiota, including SFB, can regulate pulmonary adaptive immune responses.
Related Papers (5)
Diet-microbiota interactions and their implications for healthy living.
Ian B. Jeffery,Paul W. O'Toole +1 more