Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease.
Cielo García-Montero,Oscar Fraile-Martínez,Ana M Gómez-Lahoz,Leonel Pekarek,Alejandro J. Castellanos,Fernando Noguerales-Fraguas,Santiago Coca,Santiago Coca,Luis G. Guijarro,Natalio García-Honduvilla,Natalio García-Honduvilla,Ángel Asúnsolo,Ángel Asúnsolo,Lara Sanchez-Trujillo,Lara Sanchez-Trujillo,Guillermo Lahera,Guillermo Lahera,Julia Buján,Julia Buján,Jorge Monserrat,Jorge Monserrat,Melchor Alvarez-Mon,Miguel Angel Alvarez-Mon,Miguel A Ortega +23 more
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TLDR
In this article, the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.Abstract:
The most prevalent diseases of our time, non-communicable diseases (NCDs) (including obesity, type 2 diabetes, cardiovascular diseases and some types of cancer) are rising worldwide. All of them share the condition of an “inflammatory disorder”, with impaired immune functions frequently caused or accompanied by alterations in gut microbiota. These multifactorial maladies also have in common malnutrition related to physiopathology. In this context, diet is the greatest modulator of immune system–microbiota crosstalk, and much interest, and new challenges, are arising in the area of precision nutrition as a way towards treatment and prevention. It is a fact that the westernized diet (WD) is partly responsible for the increased prevalence of NCDs, negatively affecting both gut microbiota and the immune system. Conversely, other nutritional approaches, such as Mediterranean diet (MD), positively influence immune system and gut microbiota, and is proposed not only as a potential tool in the clinical management of different disease conditions, but also for prevention and health promotion globally. Thus, the purpose of this review is to determine the regulatory role of nutritional components of WD and MD in the gut microbiota and immune system interplay, in order to understand, and create awareness of, the influence of diet over both key components.read more
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Understanding Chronic Venous Disease: A Critical Overview of Its Pathophysiology and Medical Management
Miguel A Ortega,Oscar Fraile-Martínez,Oscar Fraile-Martínez,Cielo García-Montero,Cielo García-Montero,Miguel Angel Alvarez-Mon,Miguel Angel Alvarez-Mon,Chen Chaowen,Fernando Ruiz-Grande,Leonel Pekarek,Leonel Pekarek,Jorge Monserrat,Jorge Monserrat,Ángel Asúnsolo,Natalio García-Honduvilla,Natalio García-Honduvilla,Melchor Alvarez-Mon,Melchor Alvarez-Mon,Julia Buján,Julia Buján +19 more
TL;DR: In this paper, the authors present a review of the current knowledge of chronic venous disease, including its epidemiology, etiology, and risk factors, emphasizing the pathophysiology and medical care of these patients, including clinical manifestations, diagnosis, and treatments.
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Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights.
Bernard Srour,Melissa C. Kordahi,Erica Bonazzi,Mélanie Deschasaux-Tanguy,Mathilde Touvier,Benoit Chassaing +5 more
TL;DR: In this article , an overview of the current data that highlight an association between ultra-processed food consumption and various chronic diseases, with a focus on epidemiological evidence and mechanistic insights involving the intestinal microbiota.
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Gut Microbiota Metabolites in Major Depressive Disorder—Deep Insights into Their Pathophysiological Role and Potential Translational Applications
Miguel A Ortega,Miguel Angel Alvarez-Mon,C. García-Montero,Oscar Fraile-Martínez,Luis G. Guijarro,Guillermo Lahera,Jorge Monserrat,Paula Valls,Fernando Mora,Roberto Rodriguez-Jimenez,Javier Quintero,Melchor Alvarez-Mon +11 more
TL;DR: The main microbial metabolites (short-chain fatty acids -SCFAs-, bile acids, amino acids, tryptophan -trp- derivatives, and more), their signaling pathways and functions will be summarized to explain part of MDD pathophysiology.
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The Mediterranean Diet: An Update of the Clinical Trials
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Bacillus subtilis-Based Probiotic Improves Skeletal Health and Immunity in Broiler Chickens Exposed to Heat Stress.
TL;DR: In this paper, the effects of the probiotic Bacillus subtilis on skeletal health of broiler chickens exposed to heat stress was investigated. But the authors focused on the effects on the health and welfare of the animals.
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