Journal ArticleDOI
Omega-3 Fatty Acids in the Prevention-Management of Cardiovascular Disease
TLDR
Fish oil has been shown to reduce ventricular arrhythmias and to be more beneficial than currently used pharmacologic agents and the dose, duration, and mechanisms involved in the prevention and management of cardiovascular disease following omega-3 fatty acid ingestion or supplementation need to be investigated by double blind controlled clinical trials.Abstract:
Epidemiologic studies show that populations who eat fish versus those who do not have a reduced death rate from cardiovascular disease. Experimental studies have shown that omega-3 fatty acids affect the function of cells involved in atherothrombosis in numerous ways, including the modification of eicosanoid products in the cyclooxygenase and lipoxygenase pathways, the reduced synthesis of cytokines and platelet-derived growth factor, and alterations of leukocyte and endothelial cell properties. Intervention studies in patients with restenosis, myocardial infarction, and cardiac arrhythmias with omega-3 fatty acid supplementation have been addressed in several clinical studies. The ingestion of omega-3 fatty acids following one episode of myocardial infarction appears to decrease the rate of cardiac death. These effects of omega-3 fatty acids appear to be due to their antiarrhythmic properties. In fact, fish oil has been shown to reduce ventricular arrhythmias and to be more beneficial than currently used pharmacologic agents. The dose, duration, and mechanisms involved in the prevention and management of cardiovascular disease following omega-3 fatty acid ingestion or supplementation need to be investigated by double blind controlled clinical trials.read more
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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione
Roberto Marchioli,Federica Barzi,Elena Bomba,Carmine Chieffo,Domenico Di Gregorio,Rocco Di Mascio,Maria Grazia Franzosi,Enrico Geraci,Giacomo Levantesi,Aldo P. Maggioni,Loredana Mantini,Rosa Maria Marfisi,G. Mastrogiuseppe,Nicola Mininni,Gian Luigi Nicolosi,Massimo Santini,Carlo Schweiger,Luigi Tavazzi,Gianni Tognoni,Corrado Tucci,Franco Valagussa +20 more
TL;DR: In this article, the authors assess the time course of the benefit of n-3 polyunsaturated fatty acids (PUFAs) on mortality documented by the GISSI-Prevenzione trial in patients surviving a recent (<3 months) myocardial infarction.
Journal ArticleDOI
The Mediterranean Diets: What Is So Special about the Diet of Greece? The Scientific Evidence
TL;DR: Analyses of the dietary pattern of the diet of Crete shows a number of protective substances, such as selenium, glutathione, high amounts of fiber, antioxidants, vitamins E and C, some of which have been shown to be associated with lower risk of cancer, including cancer of the breast.
Journal ArticleDOI
Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension
Richard J. Woodman,Trevor A. Mori,Valerie Burke,Ian B. Puddey,Gerald F. Watts,Lawrence J. Beilin +5 more
TL;DR: EPA and DHA had similar benefits on lipids but adverse effects on short-term glycemic control in hypertensive diabetic patients and the overall implications for cardiovascular disease require long-term evaluation.
Journal ArticleDOI
Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins
Matthew Spite,Charles N. Serhan +1 more
TL;DR: The biosynthesis and actions of proresolving lipid mediators are overview and update, highlighting their diverse protective roles relevant to vascular systems and their relation to aspirin and statin therapies.
References
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Journal ArticleDOI
Omega-3 fatty acids in health and disease and in growth and development
TL;DR: Omega 3 fatty acids decrease the number and size of tumors and increase the time elapsed before appearance of tumors, which is essential for the normal functional development of the retina and brain, particularly in premature infants.
Journal ArticleDOI
Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease.
M de Lorgeril,Serge Renaud,P Salen,I Monjaud,Nicole Mamelle,Jean-Louis Martin,J. Guidollet,P Touboul,J. Delaye +8 more
TL;DR: An alpha-linolenic acid-rich Mediterranean diet seems to be more efficient than presently used diets in the secondary prevention of coronary events and death.
Journal ArticleDOI
Fish oils and plasma lipid and lipoprotein metabolism in humans: a critical review.
TL;DR: Fish oil or linolenic acid may serve as alternative sources of long-chain n-3 FAs, but further studies will be needed to document their hypolipidemic and/or antiatherogenic effects.
Journal ArticleDOI
The Role of Interleukin-1 in Disease
TL;DR: The interleukin-1 stimulates the release of pituitary hormones, increases the synthesis of collagenases, resulting in the destruction of cartilage, and stimulates the production of prostaglandins, leading to a decrease in the pain threshold.
Journal ArticleDOI
The composition of food consumed by Greenland Eskimos.
H O Bang,Jørn Dyerberg,N Hjøorne +2 more
TL;DR: Food specimens have been collected from Greenland Eskimo hunters and their wives, in all seven persons, on seven consecutive days, and their food was found to contain more protein and less carbohydrates than average Danish food and an almost equal amount of fat.