Journal ArticleDOI
One‐pot Combinatorial Synthesis of Benzo[4,5]imidazo‐[1,2‐a]thiopyrano[3,4‐d]pyrimidin‐4(3H)‐one Derivatives
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TLDR
A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-THiopyran-3,5(4H,6H)-dione, and 1H-benzo[d]IMIDazol-2-amine in glacial acetic acid.Abstract:
A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-thiopyran-3,5(4H,6H)-dione, and 1H-benzo[d]imidazol-2-amine in glacial acetic acid. This protocol features mild reaction conditions, high yields and short reaction time.read more
Citations
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Diversity Oriented Syntheses of Conventional Heterocycles by Smart Multi Component Reactions (MCRs) of the Last Decade
TL;DR: A collection of smart multicomponent reactions (MCRs) with continuative post condensation cyclizations (PCCs) is presented to construct conventional three- to seven-membered heterocyclic compounds in diversity oriented syntheses (DOS).
Journal ArticleDOI
Alum (KAl(SO4)2·12H2O) Catalyzed Multicomponent Transformation: Simple, Efficient, and Green Route to Synthesis of Functionalized Spiro[chromeno[2,3‐d]pyrimidine‐5,3′‐indoline]‐tetraones in Ionic Liquid Media
TL;DR: The combination of isatin, barbituric acid, and cyclohexane-1,3-dione derivatives in the presence of alum (KAl(SO4)2·12H2O) as a catalyst for 15 min was found to be a suitable and efficient method for the synthesis of spiro[chromeno[2,3d]pyrimidine-5,3′-indoline]-tetraones as discussed by the authors.
Journal ArticleDOI
α-Aminoazoles/azines: key reaction partners for multicomponent reactions
TL;DR: Aromatic α-aminoazaheterocycles are the focus of significant investigations and exploration by researchers owing to their key role in diverse biological and physiological processes as mentioned in this paper, and therefore, the synthesis of a structurally diverse range of their derivatives through simple and convenient methods represents a vital field of synthetic organic chemistry.
Journal ArticleDOI
Pyrimido[1,2-a]benzimidazoles: synthesis and perspective of their pharmacological use
Victor V. Fedotov,Vladimir L. Rusinov,Vladimir L. Rusinov,Evgeny N. Ulomsky,Evgeny N. Ulomsky,Evgeny M. Mukhin,Evgeny B. Gorbunov,Oleg N. Chupakhin,Oleg N. Chupakhin +8 more
TL;DR: The authors presented data on the synthesis as well as studies of new derivatives of pyrimido[1,2-a]benzimidazoles published over the last decade.
References
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Journal ArticleDOI
Multicomponent Reactions with Isocyanides.
Alexander Dömling,Ivar Ugi +1 more
TL;DR: MCRs and especially MCRs with isocyanides offer many opportunities to attain new reactions and basic structures, however, this requires that the chemist learns the "language" of M CRs, something that this review wishes to stimulate.
BookDOI
Multicomponent Reactions: ZHU:MULTICOMPONENT REACTIONS O-BK
Jieping Zhu,Hugues Bienaymé +1 more
Journal ArticleDOI
Applications of Multicomponent Reactions to the Synthesis of Diverse Heterocyclic Scaffolds
TL;DR: This work has shown that the optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products.
Journal ArticleDOI
Benzimidazole condensed ring systems: new synthesis and antineoplastic activity of substituted 3,4-dihydro- and 1,2,3,4-tetrahydro-benzo[4,5]imidazo[1,2-a]pyrimidine derivatives.
TL;DR: In this paper, a series of substituted 3,4-dihydro- and 1,2,3, 4-tetrahydrobenzo[4,5]imidazo[1,2-a]pyrimidine-2-one derivatives were synthesized via one-pot two-component thermal cyclization reaction.
Journal ArticleDOI
Synthesis of fully substituted pyrazolo[3,4-b]pyridine-5-carboxamide derivatives via a one-pot four-component reaction
TL;DR: In this paper, a one-pot four-component reaction of an aliphatic or aromatic amine, diketene, an aromatic aldehyde and 1,3-diphenyl-1H-pyrazol-5-amine in the presence of p-toluenesulfonic acid as a catalyst has been developed.