Journal ArticleDOI
One-pot synthesis of chromenylfurandicarboxylates and cyclopenta[b]chromenedicarboxylates involving zwitterionic intermediates. A DFT investigation on the regioselectivity of the reaction.
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TLDR
The reactants, intermediate zwitterions, transition structures, and intermediate products, leading to the final products, were optimized using the B3LYP functional with the 6-31G(d) basis set and the structures of the products were elucidated by 1D and 2D NMR experiments.Abstract:
The reaction of 1:1 zwitterionic intermediates generated in situ from either tert-butylisocyanide or cyclohexylisocyanide and acetylenedicarboxylates with 3-formylchromones is described, whereupon ...read more
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Synthesis, structure-activity relationship of novel substituted 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates as potential anti-mycobacterial and anticancer agents.
B. China Raju,R. Nageswara Rao,Pathi Suman,Perumal Yogeeswari,Dharmarajan Sriram,Thokhir Basha Shaik,Shasi V. Kalivendi +6 more
TL;DR: This is the first report assigning in vitro anti-mycobacterial, anticancer and structure-activity relationship for this new class of 4H-chromen-1,2,3,4-tetrahydropyrimidine-5-carboxylates.
Journal ArticleDOI
1,5-Benzoxazepines vs 1,5-benzodiazepines. One-pot microwave-assisted synthesis and evaluation for antioxidant activity and lipid peroxidation inhibition
Constantinos G. Neochoritis,Constantinos A. Tsoleridis,Julia Stephanidou-Stephanatou,Christos Kontogiorgis,Dimitra Hadjipavlou-Litina +4 more
TL;DR: Structural assignments of the new compounds as well as complete assignment of (1)H and (13)C NMR signals have been unambiguously achieved on the basis of the analysis of their (1D and 2D), IR, MS, and elemental analysis data.
Journal ArticleDOI
Synthesis, Reactions and Uses of Isocyanides in Organic Synthesis. An Update
TL;DR: Isocyanides were formally discovered by Gautier1 and Hofmann2 in 1867 but the history of isocyanide chemistry in fact predates this discovery as mentioned in this paper.
Journal ArticleDOI
Synthesis of Heterocycles by Formal Cycloadditions of Isocyanides
TL;DR: This Focus Review aims at mapping this reactivity and at providing insight into the relationship between the various reported reaction partners and the observed reactivity modes.
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Palladium-catalyzed cycloisomerization and aerobic oxidative cycloisomerization of homoallenyl amides: a facile and divergent approach to 2-aminofurans.
TL;DR: Preliminary mechanistic studies show that peroxide may be a key intermediate for this Pd-catalyzed radical aerobic oxidative cycloisomerization of homoallenyl amides.
References
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Journal ArticleDOI
Pyrane, 78. Über Reaktionen von 3‐Formylchromonen mit Diphenylketen
Fritz Eiden,Irmgard Breugst +1 more
TL;DR: Pyrans, 78. as discussed by the authors showed that 3-formylchromones with diphenylketene can give rise to enamines, pyrazoles, pyrimidines, and 1,5-benzodiazepines.
Journal ArticleDOI
4-Picoline-catalyzed hetero-Diels–Alder type reactions: one-pot synthesis of pyrano[4,3-c]chromenes
Michael A. Terzidis,Eleni Dimitriadou,Constantinos A. Tsoleridis,Julia Stephanidou-Stephanatou +3 more
TL;DR: In this article, an organocatalytic hetero-Diels-Alder type reaction between α,β-unsaturated aldehydes and acetylenedicarboxylates is achieved which offers an efficient one-pot access to a new class of pyrano[4,3-c]chromenes from simple and readily available starting materials under mild reaction conditions.
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One pot synthesis of 4-(2-hydroxybenzoyl)-pyrazoles from 3-formylchromones under microwave irradiation in solvent free conditions
TL;DR: In this article, the synthesis of 4-(-2-hydroxybenzoyl)pyrazoles was achieved in a single step by the reaction of 3-formylchromones with Phenylhydrazine or TosylHydrazine under microwave irradiation without a solvent.
Journal ArticleDOI
Facile One-Pot Three-Component Synthesis of Functionalized Pyridylfuran-2-amines
TL;DR: The reactive 1':'1 zwitterionic intermediates generated in situ from the reaction between a series of isocyanides and diaroylacetylenes were trapped by pyridine carbaldehydes to yield highly functionalized 5-pyridylfuran-2-amines in good yields as mentioned in this paper.
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A modified and green methodology for preparation of polysubstituted furans
TL;DR: In this article, a simple, one-pot and green methodology for preparation of polysubstituted furans by reaction of aromatic aldehydes, DMAD, and alkylisocyanides in water and at room temperature was introduced.