Journal ArticleDOI
One-pot synthesis of pH-sensitive poly(RGD-co-β-amino ester)s for targeted intracellular drug delivery
TLDR
TheDOX-encapsulated copolymer nanoparticles with the targeted RGD peptide exhibited higher efficiency to kill U87 human glioblastoma cancer cells than that without RGD, which was further proved by cellular uptake of DOX-loaded nanoparticles.About:
This article is published in Polymer Chemistry.The article was published on 2014-01-01. It has received 46 citations till now. The article focuses on the topics: Tertiary amine & Ethylene glycol.read more
Citations
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Self-Assembled Peptide-Based Nanomaterials for Biomedical Imaging and Therapy.
TL;DR: This review highlights the importance of self‐assembled peptide nanostructures for nanomedicine and can facilitate further knowledge and understanding of these nanosystems toward clinical translation.
Journal ArticleDOI
In Situ Formation of Nanofibers from Purpurin18‐Peptide Conjugates and the Assembly Induced Retention Effect in Tumor Sites
TL;DR: A responsive small-molecule precursor is prepared that simultaneously self-assembles into nanofibers in tumor sites that exhibit an assembly-induced retention effect, which results in an improved PA imaging signal and enhanced therapeutic efficacy.
Journal ArticleDOI
Polymeric nanoparticles promote macrophage reversal from M2 to M1 phenotypes in the tumor microenvironment.
Yi Wang,Yi Wang,Yao-Xin Lin,Yao-Xin Lin,Sheng-Lin Qiao,Sheng-Lin Qiao,Hong-Wei An,Hong-Wei An,Yang Ma,Yang Ma,Zeng-Ying Qiao,R. P. Yeshan J. Rajapaksha,R. P. Yeshan J. Rajapaksha,Hao Wang,Hao Wang +14 more
TL;DR: The strategy was to design a microenvironment-responsive material for local macrophage modification to overcome the physiological barrier of solid tumors and achieve immunomodulation in the microenvironment for cancer therapy, with negligible cytotoxicity.
Journal ArticleDOI
Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo
Yi Wang,Yao-Xin Lin,Zeng-Ying Qiao,Hong-Wei An,Sheng-Lin Qiao,Lei Wang,R. P. Yeshan J. Rajapaksha,Hao Wang +7 more
TL;DR: The polymer-beclin-1 (P-Bec1) nanoparticles display enhanced cytotoxicity to breast cancer cells through induction of autophagy, and overcomes two major limitations of the haploinsufficient tumor suppressor Bec1 compared to small-molecule drugs.
Journal ArticleDOI
Tumor-Triggered Geometrical Shape Switch of Chimeric Peptide for Enhanced in Vivo Tumor Internalization and Photodynamic Therapy.
TL;DR: In this article, a tumor extracellular acidity-responsive chimeric peptide with geometrical shape switch is designed for enhanced tumor internalization and photodynamic therapy and suggested that fusing tumor microenvironment with geometric shape switch should be a promising strategy for targeted drug delivery.
References
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Journal ArticleDOI
Block copolymer micelles for drug delivery: design, characterization and biological significance
TL;DR: The utility of polymeric micelles formed through the multimolecular assembly of block copolymers as novel core-shell typed colloidal carriers for drug and gene targeting and their feasibility as non-viral gene vectors is highlighted.
Journal ArticleDOI
Nanoparticle and targeted systems for cancer therapy.
TL;DR: This review explores recent work directed towards more targeted treatment of cancer, whether through more specific anti-cancer agents or through methods of delivery, including delivery by avoiding the reticuloendothelial system, utilizing the enhanced permeability and retention effect and tumor-specific targeting.
Journal ArticleDOI
Polymer Therapeutics: Concepts and Applications
Rainer Haag,Felix Kratz +1 more
TL;DR: An overview of polymer therapeutics is presented with a focus on concepts and examples that characterize the salient features of the drug-delivery systems.
Journal ArticleDOI
Stimuli-responsive polymersomes for programmed drug delivery.
TL;DR: In this article, recent advances in stimuli-sensitive polymersomes have been reviewed, and perspectives on future developments have been discussed.
Journal ArticleDOI
Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA
David M. Lynn and,Robert Langer +1 more
TL;DR: Both the polymers and their degradation products were determined to be noncytotoxic relative to poly(ethylene imine), a polymer conventionally employed as a synthetic transfection vector.
Related Papers (5)
Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA
David M. Lynn and,Robert Langer +1 more