Osteoarthritis as a disease of mechanics
David T. Felson,David T. Felson +1 more
Reads0
Chats0
TLDR
It is contended that the mechanically induced joint injury leads to variable inflammatory responses but that the role of this inflammation in worsening structural damage in an already osteoarthritic joint has not yet been proven.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2013-01-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Osteoarthritis.read more
Citations
More filters
Journal ArticleDOI
Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms.
Michelle Hall,Michelle Hall,Sally Doherty,Philip Courtney,Khalid Latief,Weiya Zhang,Michael Doherty +6 more
TL;DR: The degree to which these features reflect “active inflammation” is questionable and they may be better considered as part of the total organ pathology in OA and further studies are warranted to confirm these findings.
Journal ArticleDOI
MRI findings predict radiographic progression and development of erosions in hand osteoarthritis
Ida K. Haugen,Barbara Slatkowsky-Christensen,Pernille Bøyesen,S. Sesseng,Désirée van der Heijde,Tore K Kvien +5 more
TL;DR: BMLs, synovitis and JSN were the strongest predictors for radiographic progression and future studies should explore whether reducing BMLs and inflammation can decrease the risk of structural progression.
Journal ArticleDOI
Diabetes Is Associated With Increased Hand Pain in Erosive Hand Osteoarthritis: Data From a Population-Based Study
TL;DR: To explore factors related to hand pain in persons with radiographic hand osteoarthritis (OA), a large number of subjects were diagnosed with at least some form of OA.
Journal ArticleDOI
Gait Characteristics Associated With a Greater Increase in Medial Knee Cartilage T1ρ and T2 Relaxation Times in Patients Undergoing Anterior Cruciate Ligament Reconstruction.
Hsiang-Ling Teng,Hsiang-Ling Teng,Daniel Wu,Favian Su,Valentina Pedoia,Richard B. Souza,C. Benjamin Ma,Xiaojuan Li +7 more
TL;DR: A higher KFM, KFA, and vGRF during gait, especially at 6 months after ACLR, were associated with greater deterioration of MTFJ cartilage health at later time points.
Journal ArticleDOI
Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases.
TL;DR: The need to combine bone, cartilage and other tissues to form an interactive microphysiological system (MPS) to fully capture the biological complexity and mechanical functions of the osteochondral junction of the articular joint is addressed.
References
More filters
Journal ArticleDOI
Knee joint changes after meniscectomy
TL;DR: It seems likely that narrowing of the joint space will predispose to early degenerative changes, but a connection between these appearances and later osteoarthritis is not yet established and is too indefinite to justify clinical deductions.
Journal ArticleDOI
The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis
TL;DR: This is the first demonstration that in primary knee OA varus alignment increases risk of medial OA progression, that valgus alignment increased risk of lateral OA progress, that burden of malalignment predicts decline in physical function, and that these effects can be detected after as little as 18 months of observation.
Journal ArticleDOI
Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
TL;DR: The results suggest that the baseline adduction moment of the knee, which reflects the dynamic load on the medial compartment, can predict radiographic OA progression at the six year follow up in patients with medial compartment knee OA.
Journal ArticleDOI
Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis.
TL;DR: A systematic review of cohort and case-control studies evaluating the association of demographic, comorbid, and other patient-determined factors with onset of knee OA found there are identifiable factors which can be targeted for prevention of disabling knee pain.
Journal ArticleDOI
A comparison of four models of total knee-replacement prostheses
TL;DR: The geometric prosthesis was the best condylar prosthesis for osteoarthritis with moderate to severe deformity, but gave the worst results in knees with rheumatoid arthritis.
Related Papers (5)
Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
Roy D. Altman,E. Asch,Daniel Bloch,Giles G. Bole,David G. Borenstein,Kenneth D. Brandt,Wallace C. Christy,Cooke Td,Robert A. Greenwald,Marc C. Hochberg,David S. Howell,David L. Kaplan,William J. Koopman,Selden Longley,Henry J. Mankin,Dennis J. McShane,Thomas A. Medsger,Robert F. Meenan,William M. Mikkelsen,Roland W. Moskowitz,William A. Murphy,B. Rothschild,Mark R. Segal,Leon Sokoloff,Frederick Wolfe +24 more