Osteoarthritis as a disease of mechanics
David T. Felson,David T. Felson +1 more
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TLDR
It is contended that the mechanically induced joint injury leads to variable inflammatory responses but that the role of this inflammation in worsening structural damage in an already osteoarthritic joint has not yet been proven.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2013-01-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Osteoarthritis.read more
Citations
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Knee osteoarthritis has doubled in prevalence since the mid-20th century
Ian J. Wallace,Steven Worthington,David T. Felson,Robert Jurmain,Kimberly T. Wren,Heli Maijanen,Robert J. Woods,Daniel E. Lieberman +7 more
TL;DR: It is shown that knee OA long existed at low frequencies, but since the mid-20th century, the disease has doubled in prevalence, contradict the view that the recent surge in knee osteoarthritis occurred simply because people live longer and are more commonly obese.
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Inflammation in joint injury and post-traumatic osteoarthritis
TL;DR: A vigorous inflammatory response occurs very early after joint injury but is then sustained at a lower level at the later phases, which should provide hope for the future of disease modification tin PTOA.
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Cartilage damage in osteoarthritis and rheumatoid arthritis—two unequal siblings
Thomas Pap,Adelheid Korb-Pap +1 more
TL;DR: In a proposed model of RA as a site-specific manifestation of a systemic autoimmune disorder, early cartilage damage in the context of immune activation leads to a specific cellular response within articular joints that could explain not only the organ specificity of RA, but also the chronic nature and perpetuation of the disease.
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Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial.
L. Stefan Lohmander,L. Stefan Lohmander,Scarlett Hellot,Don Dreher,Eduard F. W. Krantz,Dawie S. Kruger,Ali Guermazi,Felix Eckstein +7 more
TL;DR: To evaluate the efficacy and safety of intraarticular sprifermin (recombinant human fibroblast growth factor 18) in the treatment of symptomatic knee osteoarthritis (OA).
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An Update on the Pathophysiology of Osteoarthritis
Ali Mobasheri,Mark E. Batt +1 more
TL;DR: In this article, the authors focus on the pathophysiological aspects of osteoarthritis development and progression, review the current concepts and discuss the future of personalized medicine for OA.
References
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Incidental meniscal findings on knee MRI in middle-aged and elderly persons
Martin Englund,Ali Guermazi,Daniel Gale,David J. Hunter,Piran Aliabadi,Margaret Clancy,David T. Felson +6 more
TL;DR: Investigative meniscal findings on MRI of the knee are common in the general population and increase with increasing age, and among persons with radiographic evidence of osteoarthritis, the prevalence of a meniscal tear was 63% among those with knee pain, aching, or stiffness on most days and 60% amongst those without these symptoms.
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Knee Osteoarthritis After Anterior Cruciate Ligament Injury A Systematic Review
TL;DR: No universal methodological radiologic classification method exists, making comparisons of the studies and stating firm conclusions on the prevalence of knee osteoarthritis more than 10 years after anterior cruciate ligament injury difficult.
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Bone marrow edema and its relation to progression of knee osteoarthritis.
David T. Felson,Sara J. McLaughlin,Joyce Goggins,Michael P. LaValley,M. Elon Gale,Saara Totterman,Wei Li,Christopher Hill,Daniel Gale +8 more
TL;DR: The relation of bone marrow edema lesions to joint space loss in patients with osteoarthritis was investigated, to evaluate whether these lesions were associated with malalignment, and to determine whether some of the relation of marrow lesions to progression could be explained by their association withmalalignment.
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Knee osteoarthritis after meniscectomy : Prevalence of radiographic changes after twenty-one years, compared with matched controls
TL;DR: Surgical removal of a meniscus following knee injury represents a significant risk factor for radiographic tibiofemoral OA, with a relative risk of 14.0 after 21 years.
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Etiology of Ankle Osteoarthritis
Victor Valderrabano,Victor Valderrabano,Monika Horisberger,Iain Russell,Hugh Dougall,Beat Hintermann +5 more
TL;DR: In the majority of patients with ankle OA the average tibiotalar alignment is varus regardless of the underlying etiology, and the study showed trauma is the main cause of ankles OA and primary OA is rare.
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