Osteoarthritis as a disease of mechanics
David T. Felson,David T. Felson +1 more
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TLDR
It is contended that the mechanically induced joint injury leads to variable inflammatory responses but that the role of this inflammation in worsening structural damage in an already osteoarthritic joint has not yet been proven.About:
This article is published in Osteoarthritis and Cartilage.The article was published on 2013-01-01 and is currently open access. It has received 463 citations till now. The article focuses on the topics: Osteoarthritis.read more
Citations
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It's not all about the knee adduction moment: the role of the knee flexion moment in medial knee joint loading.
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Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis
Dzenita Muratovic,Dzenita Muratovic,David M. Findlay,Flavia M. Cicuttini,Anita E. Wluka,Yea-Rin Lee,Yea-Rin Lee,Julia S. Kuliwaba,Julia S. Kuliwaba +8 more
TL;DR: Increased bone matrix microdamage and altered vasculature in the subchondral bone of BMLs is consistent with overloading and vascular contributions to the formation of these lesions, offering potential targets for the treatment and prevention of knee OA.
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Changes in biomechanical risk factors for knee osteoarthritis and their association with 5-year clinically important improvement after limb realignment surgery
Trevor B. Birmingham,Trevor B. Birmingham,Rebecca F. Moyer,Rebecca F. Moyer,Rebecca F. Moyer,Kristyn M. Leitch,Kristyn M. Leitch,Bert M. Chesworth,Dianne Bryant,Kevin Willits,Kevin Willits,Robert Litchfield,Robert Litchfield,Peter J. Fowler,Peter J. Fowler,J.R. Giffin,J.R. Giffin +16 more
TL;DR: Substantial improvements in biomechanical risk factors and patient-reported outcomes are observed 5 years after medial opening wedge HTO and the surgery-induced change in load distribution during walking is significantly associated with long-term clinically important improvement.
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Subject-specific calibration of neuromuscular parameters enables neuromusculoskeletal models to estimate physiologically plausible hip joint contact forces in healthy adults
TL;DR: It is suggested that the EMG-assisted mode combined with minimise joint moments error and peak HJCF calibration is preferable for the estimation of HJ CF and generation of realistic load distribution across muscles.
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A calibrated EMG-informed neuromusculoskeletal model can appropriately account for muscle co-contraction in the estimation of hip joint contact forces in people with hip osteoarthritis
TL;DR: It is suggested that the EMG-assisted neural control solution may estimate more physiologically plausible HJCF than static optimisation in a population with high levels of co-contraction, such as hip OA.
References
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Knee joint changes after meniscectomy
TL;DR: It seems likely that narrowing of the joint space will predispose to early degenerative changes, but a connection between these appearances and later osteoarthritis is not yet established and is too indefinite to justify clinical deductions.
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The Role of Knee Alignment in Disease Progression and Functional Decline in Knee Osteoarthritis
TL;DR: This is the first demonstration that in primary knee OA varus alignment increases risk of medial OA progression, that valgus alignment increased risk of lateral OA progress, that burden of malalignment predicts decline in physical function, and that these effects can be detected after as little as 18 months of observation.
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Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis
TL;DR: The results suggest that the baseline adduction moment of the knee, which reflects the dynamic load on the medial compartment, can predict radiographic OA progression at the six year follow up in patients with medial compartment knee OA.
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Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis.
TL;DR: A systematic review of cohort and case-control studies evaluating the association of demographic, comorbid, and other patient-determined factors with onset of knee OA found there are identifiable factors which can be targeted for prevention of disabling knee pain.
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A comparison of four models of total knee-replacement prostheses
TL;DR: The geometric prosthesis was the best condylar prosthesis for osteoarthritis with moderate to severe deformity, but gave the worst results in knees with rheumatoid arthritis.
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