Overnutrition, mTOR signaling, and cardiovascular diseases.
Reads0
Chats0
TLDR
This review focuses on the effects that the interaction between excess intake of nutrients and enhanced mTOR signaling have on the promotion of obesity-associated diseases and potential therapeutic strategies involving targeting m TOR signaling.Abstract:
The prevalence of obesity and associated medical disorders has increased dramatically in the United States and throughout much of the world in the past decade. Obesity, induced by excess intake of carbohydrates and fats, is a major cause of Type 2 diabetes, hypertension, and the cardiorenal metabolic syndrome. There is emerging evidence that excessive nutrient intake promotes signaling through the mammalian target of rapamycin (mTOR), which, in turn, may lead to alterations of cellular metabolic signaling leading to insulin resistance and obesity-related diseases, such as diabetes, cardiovascular and kidney disease, as well as cancer. While the pivotal role of mTOR signaling in regulating metabolic stress, autophagy, and adaptive immune responses has received increasing attention, there remain many gaps in our knowledge regarding this important nutrient sensor. For example, the precise cellular signaling mechanisms linking excessive nutrient intake and enhanced mTOR signaling with increased cardiovascular and kidney disease, as well as cancer, are not well understood. In this review, we focus on the effects that the interaction between excess intake of nutrients and enhanced mTOR signaling have on the promotion of obesity-associated diseases and potential therapeutic strategies involving targeting mTOR signaling.read more
Citations
More filters
Journal ArticleDOI
Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy
TL;DR: A surge in diabetic cardiomyopathy research is highlighted, current understanding of the molecular mechanisms underpinning this condition is summarized, and potential preventive and therapeutic strategies are explored.
Journal ArticleDOI
New Insights for Oxidative Stress and Diabetes Mellitus.
TL;DR: The mechanistic target of rapamycin, silent mating type information regulation 2 homolog 1 (S. cerevisiae) (SIRT1), and Wnt1 inducible signaling pathway protein 1 (WISP1) are especially justified to be considered treatment targets for DM.
Journal ArticleDOI
Review: Metabolic Regulation of Inflammation in Osteoarthritis.
TL;DR: Osteoarthritis has long been considered the unique consequence of a tear and wear process leading to cartilage degradation as discussed by the authors, with the production of osteophytes being considered a reactive process of the bone to protect and stabilize the altered joint.
Journal ArticleDOI
Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade.
TL;DR: It is suggested that CA impedes PDGF-BB-induced VSMC phenotypic switching, proliferation, migration and neointima formation via inhibition of ROS/NFκB/mTOR/P70S6K signaling cascade.
Journal ArticleDOI
Endothelial Mineralocorticoid Receptor Mediates Diet-Induced Aortic Stiffness in Females
Guanghong Jia,Javad Habibi,Annayya R. Aroor,Luis A. Martinez-Lemus,Vincent G. DeMarco,Francisco I. Ramirez-Perez,Zhe Sun,Melvin R. Hayden,Gerald A. Meininger,Katelee Barrett Mueller,Iris Z. Jaffe,James R. Sowers +11 more
TL;DR: Increased ECMR signaling associated with consumption of a WD plays a key role in endothelial sodium channel activation, reduced nitric oxide production, oxidative stress, and inflammation that lead to aortic remodeling and stiffness in female mice.
References
More filters
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
Journal ArticleDOI
mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
Journal ArticleDOI
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
Journal ArticleDOI
Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
Yasemin Sancak,Liron Bar-Peled,Roberto Zoncu,Andrew L. Markhard,Shigeyuki Nada,David M. Sabatini +5 more
TL;DR: It is shown that amino acids induce the movement of m TORC1 to lysosomal membranes, where the Rag proteins reside, and Rag-Ragulator-mediated translocation of mTORC1 is the key event in amino acid signaling to mtorC1.
Journal ArticleDOI
Diabetes and Vascular Disease Pathophysiology, Clinical Consequences, and Medical Therapy: Part I
TL;DR: The present review will focus on the relationship of diabetes mellitus and atherosclerotic vascular disease, highlighting pathophysiology and molecular mechanisms (Part I) and clinical manifestations and management strategies (Part II).