Journal ArticleDOI
Paclitaxel-HSA interaction. Binding sites on HSA molecule.
TLDR
The relative fluorescence intensity of the paclitaxel-bound HSA decreased, suggesting that perturbation around the Trp 214 residue took place, and this was confirmed by the destabilization of the warfarin binding site, which includes Trp214, and high affinity bilirubin binding sites located in subdomain IIA.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2004-06-15. It has received 144 citations till now. The article focuses on the topics: Fluorescence spectrometry & Human serum albumin.read more
Citations
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Journal ArticleDOI
Challenges in Development of Nanoparticle-Based Therapeutics
TL;DR: Challenges likely to be encountered during the development and approval of nanoparticle-based therapeutics are summarized, and potential strategies for drug developers and regulatory agencies to accelerate the growth of this important field are discussed.
Journal ArticleDOI
Binding analysis of glycyrrhetinic acid to human serum albumin: fluorescence spectroscopy, FTIR, and molecular modeling.
TL;DR: Thermodynamic analysis and computational modeling indicated that GEA could bind to the site I of HSA and hydrophobic interaction was the major acting force for the second type of binding site, which was in agreement with the thermodynamic analysis.
Journal ArticleDOI
Precise nanomedicine for intelligent therapy of cancer
Huabing Chen,Zhanjun Gu,An Hongwei,An Hongwei,Chunying Chen,Chunying Chen,Jie Chen,Jie Chen,Ran Cui,Siqin Chen,Wei-Hai Chen,Xuesi Chen,Xuesi Chen,Xiaoyuan Chen,Zhuo Chen,Baoquan Ding,Qian Dong,Qin Fan,Ting Fu,Da-Yong Hou,Qiao Jiang,Hengte Ke,Xiqun Jiang,Gang Liu,Suping Li,Tianyu Li,Zhuang Liu,Guangjun Nie,Muhammad Ovais,Muhammad Ovais,Dai-Wen Pang,Nasha Qiu,Youqing Shen,Huayu Tian,Huayu Tian,Chao Wang,Hao Wang,Zi-Qi Wang,Huaping Xu,Jiang Fei Xu,Xiangliang Yang,Shuang Zhu,Xianchuang Zheng,Xian-Zheng Zhang,Yanbing Zhao,Weihong Tan,Weihong Tan,Xi Zhang,Yuliang Zhao +48 more
TL;DR: The recent advances of intelligent cancer nanomedicine are demonstrated, and the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanotechine including various imaging and therapeutic applications, as well as nanotoxicity is discussed.
Journal ArticleDOI
Study of the interaction between icariin and human serum albumin by fluorescence spectroscopy
TL;DR: In this article, the interaction between icariin and human serum albumin (HSA) in physiological buffer (pH 7.4) was investigated by fluorescence and UV-Vis absorption spectroscopy.
Journal ArticleDOI
Natural product-based nanoformulations for cancer therapy: Opportunities and challenges
Dharambir Kashyap,Hardeep Singh Tuli,Mükerrem Betül Yerer,Ajay Sharma,Katrin Sak,Saumya Srivastava,Anjana Pandey,Vivek Garg,Gautam Sethi,Anupam Bishayee +9 more
TL;DR: The integration of phytotherapy and nanotechnology in the clinical setting may improve pharmacological response and better clinical outcome of patients.
References
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Journal ArticleDOI
Atomic structure and chemistry of human serum albumin.
Xiao Min He,Daniel C. Carter +1 more
TL;DR: The three-dimensional structure of human serum albumin has been determined crystallographically to a resolution of 2.8 Å and should provide insight into future pharmacokinetic and genetically engineered therapeutic applications of serumalbumin.
Book ChapterDOI
Structure of serum albumin.
Daniel C. Carter,Joseph X. Ho +1 more
TL;DR: This chapter provides an insight of the findings of past significant papers with the current knowledge of the recently determined high resolution X-ray structure of serum albumin and suggests that AFP may have a higher affinity for some unknown ligands important for fetal development.
Book
All About Albumin: Biochemistry, Genetics, and Medical Applications
TL;DR: The Albumin Molecule: Its Structure and Chemical Properties and Practical Aspects: Albumin in the Laboratory.
Journal Article
Further characterization of specific drug binding sites on human serum albumin.
TL;DR: The specificity of the sites for particular drugs, even at high drug to albumin ratios, was established, and the specificity and characteristics of the two sites on human adult and neonatal sera were shown to be similar to those on crystalline HSA.