Journal ArticleDOI
Palladium-Catalyzed Dual Ligand-Enabled Alkylation of Silyl Enol Ether and Enamide under Irradiation: Scope, Mechanism, and Theoretical Elucidation of Hybrid Alkyl Pd(I)-Radical Species
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TLDR
A palladium catalyst in combination with a dual phosphine ligand system catalyzes alkylation of silyl enol ether and enamide with a broad scope of tertiary, secondary, and primary alkyl bromides under mild irradiation conditions by blue light-emitting diodes, providing a method for facile synthesis of chiral α-arylated aliphatic amines, which are of importance in medicinal chemistry research.Abstract:
We report herein that a palladium catalyst in combination with a dual phosphine ligand system catalyzes alkylation of silyl enol ether and enamide with a broad scope of tertiary, secondary, and pri...read more
Citations
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Visible Light-Induced Transition Metal Catalysis.
TL;DR: In this paper, a transition metal complex serves a double duty by harvesting photon energy and then enabling bond forming/breaking events mostly via a single catalytic cycle, thus contrasting the established dual photocatalysis in which an exogenous photosensitizer is employed.
Journal ArticleDOI
Transition Metal-Catalyzed Organic Reactions under Visible Light: Recent Developments and Future Perspectives
TL;DR: The development of transition metal (TM) catalysis for organic synthesis under visible light without recourse to typical photoredox catalysts has become a rapidly growing area of research and has b...
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Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds.
Rolando Cannalire,Sveva Pelliccia,Luca Sancineto,Ettore Novellino,Gian Cesare Tron,Mariateresa Giustiniano +5 more
TL;DR: In this paper, the authors present a review of the recent developments in the field of late stage functionalization of complex biorelevant compounds and highlight the expected future progress and potential applications.
Journal ArticleDOI
Three-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides.
Huan-Ming Huang,Peter Bellotti,Philipp Miro Pflueger,Jonas Luca Schwarz,Bastian Heidrich,Frank Glorius +5 more
TL;DR: It is shown that a modular, practical and general palladium catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substi-tution sequence mediated by visible light.
Journal ArticleDOI
Recent Advances in the Enantioselective Synthesis of Chiral Amines via Transition Metal-Catalyzed Asymmetric Hydrogenation.
TL;DR: The use of catalytic asymmetric hydrogenation (AH) in the synthesis of chiral amines bearing a stereogenic center either in the α, β, or γ position with respect to the nitrogen atom is discussed in this paper.
References
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Electron transfers in chemistry and biology
Rudolph A. Marcus,Norman Sutin +1 more
TL;DR: In this paper, the electron transfer reactions between ions and molecules in solution have been the subject of considerable experimental study during the past three decades, including charge transfer, photoelectric emission spectra, chemiluminescent electron transfer, and electron transfer through frozen media.
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Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
TL;DR: The conversion of these bench stable, benign catalysts to redox-active species upon irradiation with simple household lightbulbs represents a remarkably chemoselective trigger to induce unique and valuable catalytic processes.
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Organic Photoredox Catalysis
TL;DR: An overview of the basic photophysics and electron transfer theory is presented in order to provide a comprehensive guide for employing this class of catalysts in photoredox manifolds.
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On the Theory of Electron-Transfer Reactions. VI. Unified Treatment for Homogeneous and Electrode Reactions
TL;DR: A unified theory of homogeneous and electrochemical electron transfer rates using statistical mechanics is developed in this article, where the atomic motions inside the inner coordination shell of each reactant are treated as vibrations and the motions outside are treated by the particle description.
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Weak coordination as a powerful means for developing broadly useful C-H functionalization reactions.
TL;DR: The motivation for studying Pd-catalyzed C-H functionalization assisted by weakly coordinating functional groups is discussed, and efforts to bring reactions of this type to fruition are chronicle.