Journal ArticleDOI
Pallial and subpallial derivatives in the embryonic chick and mouse telencephalon, traced by the expression of the genes Dlx-2, Emx-1, Nkx-2.1, Pax-6, and Tbr-1
Luis Puelles,Ellen Kuwana,Eduardo Puelles,Alessandro Bulfone,Kenji Shimamura,Jerry Keleher,Susan Smiga,John L.R. Rubenstein +7 more
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TLDR
Differences in the expression topography of Tbr‐1 and Emx‐1 suggest the existence of a novel “ventral pallium” subdivision, which is an EmX‐1‐negative pallial territory intercalated between the striatum and the lateral pallium.Abstract:
Pallial and subpallial morphological subdivisions of the developing chicken telencephalon were examined by means of gene markers, compared with their expression pattern in the mouse. Nested expression domains of the genes Dlx-2 and Nkx-2.1, plus Pax-6-expressing migrated cells, are characteristic for the mouse subpallium. The genes Pax-6, Tbr-1, and Emx-1 are expressed in the pallium. The pallio-subpallial boundary lies at the interface between the Tbr-1 and Dlx-2 expression domains. Differences in the expression topography of Tbr-1 and Emx-1 suggest the existence of a novel “ventral pallium” subdivision, which is an Emx-1-negative pallial territory intercalated between the striatum and the lateral pallium. Its derivatives in the mouse belong to the claustroamygdaloid complex. Chicken genes homologous to these mouse genes are expressed in topologically comparable patterns during development. The avian subpallium, called “paleostriatum,” shows nested Dlx-2 and Nkx-2.1 domains and migrated Pax-6-positive neurons; the avian pallium expresses Pax-6, Tbr-1, and Emx-1 and also contains a distinct Emx-1-negative ventral pallium, formed by the massive domain confusingly called “neostriatum.” These expression patterns extend into the septum and the archistriatum, as they do into the mouse septum and amygdala, suggesting that the concepts of pallium and subpallium can be extended to these areas. The similarity of such molecular profiles in the mouse and chicken pallium and subpallium points to common sets of causal determinants. These may underlie similar histogenetic specification processes and field homologies, including some comparable connectivity patterns. J. Comp. Neurol. 424: 409 ‐ 438, 2000. © 2000 Wiley-Liss, Inc.read more
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Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals
Mototsugu Eiraku,Kiichi Watanabe,Mami Matsuo-Takasaki,Masako Kawada,Shigenobu Yonemura,Michiru Matsumura,Takafumi Wataya,Ayaka Nishiyama,Keiko Muguruma,Yoshiki Sasai +9 more
TL;DR: Self-organized formation of apico-basally polarized cortical tissues from ESCs using an efficient three-dimensional aggregation culture (SFEBq culture) is demonstrated and spatial and temporal aspects of early corticogenesis are recapitulated and can be manipulated in this ESC culture.
Journal ArticleDOI
Cortical Excitatory Neurons and Glia, But Not GABAergic Neurons, Are Produced in the Emx1-Expressing Lineage
Jessica A. Gorski,Tiffany Talley,Mengsheng Qiu,Luis Puelles,John L.R. Rubenstein,Kevin R. Jones +5 more
TL;DR: A strain of mice is generated that expresses the Cre recombinase in a spatial and temporal pattern like that observed for Emx1, and it is demonstrated that radial glia, Cajal-Retzius cells, glutamatergic neurons, astrocytes, and oligodendrocytic cells of most pallial structures originate from an EmX1-expressing lineage.
Journal ArticleDOI
Revised Nomenclature for Avian Telencephalon and Some Related Brainstem Nuclei
Anton Reiner,David J. Perkel,Laura L. Bruce,Ann B. Butler,András Csillag,Wayne J. Kuenzel,Loreta Medina,George Paxinos,Toru Shimizu,Georg F. Striedter,Martin Wild,Gregory F. Ball,Sarah E. Durand,Onur Gütürkün,Diane W. Lee,Claudio V. Mello,Alice Schade Powers,Stephanie A. White,Gerald E. Hough,Lubica Kubikova,Tom V. Smulders,Kazuhiro Wada,Jennifer Dugas-Ford,Scott Husband,Keiko Yamamoto,Jing Yu,Connie Siang,Erich D. Jarvis +27 more
TL;DR: The standard nomenclature that has been used for many telencephalic and related brainstem structures in birds is reviewed, with a rationale for each name change and evidence for any homologies implied by the new names.
Journal ArticleDOI
A long, remarkable journey: tangential migration in the telencephalon
Oscar Marín,John L.R. Rubenstein +1 more
TL;DR: Evidence that supports the existence of several tangential migration pathways in the telencephalon is reviewed, and recent findings that describe their regulation are summarized.
Journal Article
A long remarkable journey : tangential migration in the telencephalon : nature reviews
TL;DR: In this article, the authors review evidence that supports the existence of several tangential migration pathways in the telencephalon, and summarize recent findings that describe their regulation, and propose a new concept of corticogenesis which proposes that two distinct neuronal populations cooperate in the formation of the cortex.
References
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Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb
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Anton Reiner,David J. Perkel,Laura L. Bruce,Ann B. Butler,András Csillag,Wayne J. Kuenzel,Loreta Medina,George Paxinos,Toru Shimizu,Georg F. Striedter,Martin Wild,Gregory F. Ball,Sarah E. Durand,Onur Gütürkün,Diane W. Lee,Claudio V. Mello,Alice Schade Powers,Stephanie A. White,Gerald E. Hough,Lubica Kubikova,Tom V. Smulders,Kazuhiro Wada,Jennifer Dugas-Ford,Scott Husband,Keiko Yamamoto,Jing Yu,Connie Siang,Erich D. Jarvis +27 more