Journal ArticleDOI
Paper Microfluidics Goes Digital
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TLDR
The first example of so-called "digital microfluidics" (DMF) implemented on paper by inkjet printing is reported and it is shown that paper-based DMF devices have comparable performance to traditional photolithographically patternedDMF devices at a fraction of the cost.Abstract:
The first example of so-called "digital microfluidics" (DMF) implemented on paper by inkjet printing is reported. A sandwich enzyme-linked immunosorbent assay (ELISA) is demonstrated as an example of a complex, multistep protocol that would be difficult to achieve with capillary-driven paper microfluidics. Furthermore, it is shown that paper-based DMF devices have comparable performance to traditional photolithographically patterned DMF devices at a fraction of the cost.read more
Citations
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Journal ArticleDOI
Recent developments in paper-based microfluidic devices.
Journal ArticleDOI
Turning the Page: Advancing Paper-Based Microfluidics for Broad Diagnostic Application.
TL;DR: This review examines the advances in paper-based microfluidic diagnostics for medical diagnosis in the context of global health from 2007 to 2016 and highlights emerging health applications, such as male fertility testing and wearable diagnostics.
Journal ArticleDOI
A review of digital microfluidics as portable platforms for lab-on a-chip applications.
TL;DR: The most recent advances in the DMF platforms are discussed, and the feasibility of developing multifunctional packages for performing complete sets of processes of biochemical assays, particularly for point-of-care applications is evaluated.
Journal ArticleDOI
Electrochemistry, biosensors and microfluidics: a convergence of fields
TL;DR: The basic concepts and recent histories of electrochemistry, biosensors, and microfluidics are introduced, and how they are combining to form new application-areas, including so-called "point-of-care" systems in which measurements traditionally performed in a laboratory are moved into the field.
Journal ArticleDOI
Paper-based analytical devices for clinical diagnosis: recent advances in the fabrication techniques and sensing mechanisms.
TL;DR: This review describes currently developed cellulose and flexible transparency paper-based microfluidic devices, device fabrication techniques, and sensing technologies that are integrated with these devices and their potential in clinical settings.
References
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Journal ArticleDOI
Patterned Paper as a Platform for Inexpensive, Low‐Volume, Portable Bioassays
TL;DR: This communication describes a simple method for patterning paper to create well-defined, millimeter-sized channels, comprising hydrophilic paper bounded by hydrophobic polymer, that will become the basis for low-cost, portable, and technically simple multiplexed bioassays.
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Simple telemedicine for developing regions: camera phones and paper-based microfluidic devices for real-time, off-site diagnosis.
Andres W. Martinez,Scott T. Phillips,Emanuel Carrilho,Samuel W. Thomas,Hayat Sindi,George M. Whitesides +5 more
TL;DR: A prototype system for quantifying bioassays and for exchanging the results of the assays digitally with physicians located off-site offers new opportunities for inexpensive monitoring of health, especially in situations that require physicians to travel to patients to obtain diagnostic information that might be obtained more effectively by less valuable personnel.
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Three-dimensional microfluidic devices fabricated in layered paper and tape.
TL;DR: A method for fabricating 3D microfluidic devices by stacking layers of patterned paper and double-sided adhesive tape to carry out a range of new analytical protocols simply and inexpensively without external pumps is described.
Journal ArticleDOI
A perspective on paper-based microfluidics: Current status and future trends
TL;DR: At the current stage of its development, paper-based microfluidic system is claimed to be low-cost, easy-to-use, disposable, and equipment-free, and therefore, is a rising technology particularly relevant to improving the healthcare and disease screening in the developing world, especially for those areas with no- or low-infrastructure and limited trained medical and health professionals.
Journal ArticleDOI
Paper-Based ELISA
Chao-Min Cheng,Andres W. Martinez,Jinlong Gong,Charles R. Mace,Scott T. Phillips,Emanuel Carrilho,Emanuel Carrilho,Katherine A. Mirica,George M. Whitesides +8 more
TL;DR: It is established that P-ELISA can be used to detect and quantify antibodies to the HIV-1 envelope antigen gp41 in human serum using an anti-human IgG antibody conjugated to alkaline phosphatase (ALP) to produce a colorimetric readout.