Journal ArticleDOI
Pathogenesis of acute stroke and the role of inflammasomes
David Y. Fann,Seung-Yoon Lee,Silvia Manzanero,Prasad Chunduri,Christopher G. Sobey,Thiruma V. Arumugam,Thiruma V. Arumugam +6 more
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TLDR
The molecular structure, cellular signaling pathways and current evidence for inflammasome activation following cerebral ischemia, and the potential for future treatments for stroke that may involve targeting inflammaome formation or its products in the ischemic brain are described.About:
This article is published in Ageing Research Reviews.The article was published on 2013-09-01. It has received 258 citations till now. The article focuses on the topics: NLRP6 & Inflammasome.read more
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Phytochemicals in Ischemic Stroke
Joonki Kim,Joonki Kim,David Y. Fann,Raymond C.S. Seet,Dong-Gyu Jo,Mark P. Mattson,Mark P. Mattson,Thiruma V. Arumugam,Thiruma V. Arumugam +8 more
TL;DR: Results of preclinical studies that demonstrate beneficial effects of phytochemicals in experimental models relevant to stroke pathogenesis are described, and their possible mechanisms of action are considered.
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Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia
TL;DR: Findings suggested that Kv1.3 channel blockade effectively alleviated cerebral ischemic injury, possibly by reshaping microglial phenotypic response from M1 towards M2, compromising the activation of NLRP3 inflammasome in microglia, and inhibiting release of IL-1β.
Journal ArticleDOI
Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke
Hae In Lee,Sae-Won Lee,Nam-Gyun Kim,Kyoung-Jun Park,Byung Tae Choi,Yong-Il Shin,Hwa Kyoung Shin +6 more
TL;DR: Therapeutic interventions targeting the inflammasome via photostimulation with LED may be a novel approach to ameliorate brain injury following ischemic stroke and attenuate neuroinflammatory responses and tissue damage following isChemic stroke.
Journal ArticleDOI
Perinatal asphyxia: CNS development and deficits with delayed onset
Mario Herrera-Marschitz,T. Neira-Peña,Edgardo Rojas-Mancilla,Pablo Espina-Marchant,Daniela Esmar,Ronald Perez,Valentina Muñoz,Manuel A. Gutierrez-Hernandez,Benjamin Rivera,Nicola Simola,Diego Bustamante,Paola Morales,Peter J. Gebicke-Haerter +12 more
TL;DR: Nicotinamide rapidly distributes into the brain following systemic administration, reaching steady state concentrations sufficient to inhibit PARP-1 activity for several hours, preventing several of the long-term consequences of perinatal asphyxia, supporting the idea that nicotinamide constitutes a lead for exploring compounds with similar or better pharmacological profiles.
Journal ArticleDOI
Molecular Regulation of Cell Fate in Cerebral Ischemia: Role of the Inflammasome and Connected Pathways
TL;DR: The current knowledge of the functional role of this intracellular ‘master switch’ of inflammation is discussed with a focus on its role in ischemic stroke, neurodegeneration, and also with regard to the recent data which argues for a relevant role in other organs or biologic systems which influence stroke incidence or prognosis.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.
James C. Grotta,M Kothari,K.M.A. Welch,Joseph P. Broderick,Barbara C. Tilley,Thomas G. Brott,Marler,Patrick D. Lyden,Paul M. O'Byrne +8 more
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Thrombolysis with Alteplase 3 to 4.5 Hours After Acute Ischemic Stroke
Werner Hacke,Markku Kaste,Erich Bluhmki,Miroslav Brozman,Antoni Dávalos,Donata Guidetti,Vincent Larrue,Kennedy R. Lees,Zakaria Medeghri,Thomas Machnig,Dietmar Schneider,Rüdiger von Kummer,Nils Wahlgren,Danilo Toni +13 more
TL;DR: As compared with placebo, intravenous alteplase administered between 3 and 4.5 hours after the onset of symptoms significantly improved clinical outcomes in patients with acute ischemic stroke; altePlase was more frequently associated with symptomatic intracranial hemorrhage.
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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
TL;DR: In this article, the inflammasome is identified as a caspase-activating complex that comprises caspases-1, casp-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs.
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Origin and Physiological Roles of Inflammation
TL;DR: This work has shown that tissue stress or malfunction induces an adaptive response that is intermediate between the basal homeostatic state and a classic inflammatory response, which is referred to here as para-inflammation.